2009
DOI: 10.1161/circresaha.108.184846
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Abstract: Abstract-Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another. Their interactions not only serve to support fully functional blood vessels but also can regulate vessel assembly and differentiation or maturation. In an effort to better understand the molecular components of this heterotypic interaction, we used a 3D model of angiogenesis and screened for genes, which were modulated by coculturing of these 2 different cell types.In doing so,… Show more

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Cited by 244 publications
(282 citation statements)
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“…Differences in gene regulation by the Jagged or Dll family of ligands may provide for temporally distinct responses, since endothelial cells change their ligand expression during angiogenesis (39). Based on the known link to VSMC differentiation, it seems plausible that Notch3 receptor is a likely candidate for regulating miR-143/145 via Jag-1 signaling (15). Additionally, our present and published studies show that expression of an activated Notch1 or Notch2 receptor also recapitulates the VSMC contractile phenotype (5,29) and therefore may also activate miR-143/145.…”
Section: Discussionmentioning
confidence: 99%
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“…Differences in gene regulation by the Jagged or Dll family of ligands may provide for temporally distinct responses, since endothelial cells change their ligand expression during angiogenesis (39). Based on the known link to VSMC differentiation, it seems plausible that Notch3 receptor is a likely candidate for regulating miR-143/145 via Jag-1 signaling (15). Additionally, our present and published studies show that expression of an activated Notch1 or Notch2 receptor also recapitulates the VSMC contractile phenotype (5,29) and therefore may also activate miR-143/145.…”
Section: Discussionmentioning
confidence: 99%
“…Homotypic and heterotypic Notch signaling have been shown to be critical in defining vascular tone, maintaining vascular homeostasis, recruitment of mural cells and communication during angiogenesis (40). While Jag-1 expression in the endothelium activates Notch3 receptors in adjacent VSMC and promotes a mature contractile phenotype (15), Notch signaling between VSMC is also critical for mediating vascular remodeling after injury (41). It is likely that adjacent cell activation of VSMC Notch receptors by Jag-1 plays a pivotal role in regulating the miR-143/145 cluster and modulation of the VSMC phenotype.…”
Section: Discussionmentioning
confidence: 99%
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“…Up-regulation of Notch signaling in mural cells induces expression of smooth muscle cell (SMC) marker genes, contributes to vessel stabilization and finally to formation of robust and mature vascular networks [23]. EphrinB2/EphB4 signaling is essential for managing the adhesion/repulsion processes, intercellular contacts, and cell migration as well [24,25].…”
mentioning
confidence: 99%
“…13 By blocking the Notch signaling pathway, DAPT can significantly inhibit vSMCs proliferation and differentiation. 14 Although it has been shown that DAPT can attenuate pulmonary arterial hypertension, the pathophysiological correlate of these findings in vein graft has not been demonstrated. 15 In the present study, we proposed that Notch signaling is crucial during the process of IH in vein grafts.…”
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confidence: 99%