2008
DOI: 10.1371/journal.pgen.0040015
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Abstract: Somite segmentation depends on a gene expression oscillator or clock in the posterior presomitic mesoderm (PSM) and on read-out machinery in the anterior PSM to convert the pattern of clock phases into a somite pattern. Notch pathway mutations disrupt somitogenesis, and previous studies have suggested that Notch signalling is required both for the oscillations and for the read-out mechanism. By blocking or overactivating the Notch pathway abruptly at different times, we show that Notch signalling has no essent… Show more

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Cited by 154 publications
(209 citation statements)
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References 63 publications
(80 reference statements)
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“…Consistent with this, recent studies in zebrafish embryos suggest that the function of Notch signaling is only to synchronize the oscillations among PSM cells, and that this pathway has no other function during segmentation (Riedel-Kruse et al, 2007;Horikawa et al, 2006;Ozbudak and Lewis, 2008). However, we propose from our current data that Notch signaling has a crucial function also as an output of the segmentation clock during mouse development.…”
Section: Discussionsupporting
confidence: 89%
“…Consistent with this, recent studies in zebrafish embryos suggest that the function of Notch signaling is only to synchronize the oscillations among PSM cells, and that this pathway has no other function during segmentation (Riedel-Kruse et al, 2007;Horikawa et al, 2006;Ozbudak and Lewis, 2008). However, we propose from our current data that Notch signaling has a crucial function also as an output of the segmentation clock during mouse development.…”
Section: Discussionsupporting
confidence: 89%
“…In the PSM, oscillatory expressions are synchronized among neighboring cells. This synchronized oscillation is necessary for normal segmentation, and disruption of the synchronization results in a defective somite boundary (11)(12)(13).…”
mentioning
confidence: 99%
“…In fact, Her1/Her7 negatively regulate deltaC, influencing Notch activity in the neighboring cells and finally their own intracellular oscillations. This Delta/Notch mediated coupling mechanism results in synchronization between adjacent cells [13,[18][19][20][21].…”
Section: The Segmentation Clock Sets the Periodicity Of Somite Formationmentioning
confidence: 99%
“…In contrast to a wild-type PSM, in the absence of DeltaC, completely different mRNA localizations could be observed in PSM cells located next to each other [23]. Further support that Notch signaling serves to maintain synchrony in the PSM but is not necessary for oscillations of individual cells comes from studies where the -secretase inhibitor DAPT was used to block Notch signaling in a time controlled manner [21,24]. In these reports, it was shown that there is a delay between the time of DAPT treatment and the disruption of somite boundaries and a delay between DAPT wash and the recovery of normal somite boundaries.…”
Section: The Segmentation Clock Sets the Periodicity Of Somite Formationmentioning
confidence: 99%