Ashley R. Sandy, Josh Stoolman, Kelli Malott, Prae Pongtornpipat, Benjamin M. Segal, Ivan Maillard
Systemic inhibition of Notch signaling was previously shown to attenuate experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis in mice. Different studies attributed these effects to decreased T-bet and IFNγ expression, enhanced regulatory T cell function, reduced T cell chemotaxis to the central nervous system (CNS) or impaired Th9 cell differentiation. Interpretation of these heterogeneous findings is difficult, since past experimental strategies did not ensure complete Notch…
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