Abstract:
The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active extrusion of a wide range of drugs from the cell. To study their physiological roles, we have generated mice genetically deficient in the
mdr1b
gene [
mdr1b
(−/−) mice] and in both the
mdr1a
and
mdr1b
genes [
mdr1a/1b
(−/−) mice]. In spite of the host of functions speculatively attributed … Show more
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