Normal iron absorption and decreased red cell iron uptake in the aged

Jj, Marx

doi:10.1182/blood.v53.2.204.bloodjournal532204

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marx (8) recently showed that the high frequency of iron deficiency in the elderly is not the result of a decreased ability to absorb iron from the gut. However, of interest was the markedly decreased erythrocyte iron uptake he found in the elderly patients (mean 66 percent) compared to young adults (mean 91 per cent).…”

Section: Discussionmentioning

confidence: 99%

“…Several recent studies have indicated that there is a normal decline in the erythrocyte count, hemoglobin concentration and hematocrit value with aging (1–5). Nevertheless, other workers have concluded that there is no change in these measurements apart from pathologic processes (6–8). If there is a decline in these parameters with aging, one might assign a new normal range for geriatric patients.…”

mentioning

confidence: 95%

See 1 more Smart Citation

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Htoo

Kofkoff

Freedman

1979

J American Geriatrics Society

View full text Add to dashboard Cite

Erythrocyte parameters in 292 unselected geriatric patients were studied retrospectively. Statistically significant mean decreases compared to the laboratories' normal mean values were found in the red blood cell count (RBC), hemoglobin level, hematocrit, and mean corpuscular hemoglobin concentration; there also was a slight increase in mean corpuscular volume and mean corpuscular hemoglobin. However, when 17 patients with a hemoglobin level less than 10 gm/dl or a hematocrit reading less than 35 percent were excluded, all of the mean values for erythrocyte parameters fell within the normal range. In 71 percent of these 17 patients the etiology of the anemia was documented. Although one cannot definitely exclude a slight change in erythrocyte parameters with aging, it is concluded that the establishment of so-called new geriatric norms is premature, as the population studied included patients with various diseases. Good medical practice dictates continued evaluation and monitoring of patients in whom erythrocyte values are outside the established normal ranges.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Htoo

Kofkoff

Freedman

1979

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

“…Compared with other whole-body scanners the type described here can give a space reduction of more than 50% because of the mobile shielding. The equipment was used mainly in iron absorption studies (8,9). An oral test dose of 5 (iCi 59 Fe causes a total body burden of approximately 0.11 rem (6).…”

Section: Discussionmentioning

confidence: 99%

“…Such a whole-body scanner with mobile shielding was developed and installed in the Physical Laboratory of the National Institute of Public Health. The equipment has been intensively used in iron absorption studies (8,9). In these studies a new method was used which enabled measurements not only of iron retention but also of initial mucosal uptake and mucosal transfer of iron with simple wholebody counting (9).…”

mentioning

confidence: 99%

Simultaneous Measurement of 59Fe and 51Cr in Iron Absorption Studies Using a Whole-Body Scanner with Mobile Shielding

Marx¹,

Beld²,

Dongen³

et al. 1980

Nuklearmedizin

View full text Add to dashboard Cite

SummaryA whole-body scanner is described with a mobile shadow shield which affords a considerable reduction in space. The scanner has two Nal(Tl) scintillation crystals of 4 x 6", placed at opposite sites of the subject. Background radiation, efficiency and geometric qualities made the scanner very useful for clinical whole-body counting. The equipment was used in iron absorption studies using a double isotope technique with 59Fe and 51Cr. After ingestion of an oral test dose total body kinetics of 59Fe and 51Cr was followed up to 60 days in 4 volunteers. Between days 3 and 10 the 51Cr, which was used as an non-absorbable indicator, had left the body completely. The 59Fe reached a constant value not before day 10, indicating that iron retention cannot be measured before that time. From repeated measurement of 59Fe and 5lCr directly after ingestion until the first defaecation it could be deduced that the coefficient of variation for 59Fe was less than 1.5% with a scanning time of 600 sec, and for 51Cr less than 5%. Extreme variations in geometry, such as measurement of the activity in a beaker and of the same amount after ingestion in the body, yielded practically the same value for 59Fe. The double isotope technique made it possible to measure not only iron retention but also mucosal uptake and mucosal transfer of iron. It is pointed out that measurement of the last two parameters of iron absorption is not possible in patients with serious obstipation or with very low mucosal uptake values.

show abstract

“…Therefore, we applied a non‐invasive double‐isotope method, which comprises the ingestion of a test dose of 59 Fe together with 51 Cr. This procedure has been employed in man (M arx 1979; M arx and S tiekema 1982) and in veal calves (M iltenburg et al 1993). In rats, the method has been used once, but with non‐radioactive Cr (W ienk et al 1996).…”

Section: Introductionmentioning

confidence: 99%

The use of ⁵¹Cr as a dietary marker in rats for the determination of ⁵⁹Fe absorbability in terms of mucosal uptake and mucosal transfer of ⁵⁹Fe

Wienk

Beynen

Marx

1997

Animal Physiology Nutrition

View full text Add to dashboard Cite

Summary The use of 51CrCl3 as a non‐absorbable dietary marker for the determination of mucosal uptake and transfer of 59Fe ascorbate has been investigated in rats. In order to be useful, this marker has to satisfy two properties. Firstly, the gastrointestinal transit times of 51Cr and 59Fe have to be similar, and secondly, 51Cr absorption has to be low, and independent of the diet to which it is added. We tested these prerequisites by determination of the isotope ratios in faecal samples, and 51Cr retention in rats that were fed either a control diet, or a diet that was supplemented with ascorbic acid or phytate, which are thought to affect 51Cr absorption. The study found similar faecal 51Cr/59Fe ratios for day 1 and 2 versus day 3. 51Cr retention averaged 3.14 %, and was independent of the diet. It is concluded that this double‐isotope in vivo method is suitable for the determination of iron absorption in terms of mucosal uptake and mucosal transfer in rats, and that it may be a useful alternative for current in vivo methods that can be applied only within terminal animal experiments. Zusammenfassung Der Einsatz von 51Cr zur Bestimmung der 59Fe‐Absorption und der mukosalen Aufnahme und des mukosalen Transfer von 59Fe bei Ratten Der Einsatz von 51CrCl3 als nicht absorbierbarem Marker wurde zur Bestimmung der mukosalen Aufnahme und des mukosalen Transfer von 59Fe‐Askorbat bei Ratten geprüft. Dazu muß der Marker zwei Bedingungen erfüllen. Die 51Cr‐Absorption muß niedrig sein und zwar unabhängig von der verabreichten Diät. Ob diese Voraussetzungen erfüllt sind, wurde mit Hilfe des Verhältnisses von 51Cr zu 59Fe im Rattenkot untersucht. Dabei erhielten die Ratten eine Kontrolldiät und Diäten mit Askorbinsäure bzw. Phytat als Zusatz, da Askorbinsäure und Phytat die 51Cr‐Absorption beeinflussen sollen. Dabei wurde ein gleiches 51Cr/59Fe‐Verhältnis von Tag 1 und 2 im Vergleich zu Tag 3 gefunden. Die 51Cr‐Retention lag bei 3,14% und zwar unabhängig von der verabreichten Diät. Daraus läßt sich ableiten, daß die Doppelmarkierung in vivo für Mehrfachbestimmungen an denselben Tieren zu verschiedenen Meßzeitpunkten geeignet ist.

show abstract

Normal iron absorption and decreased red cell iron uptake in the aged

Cited by 6 publications

References 0 publications

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Simultaneous Measurement of 59Fe and 51Cr in Iron Absorption Studies Using a Whole-Body Scanner with Mobile Shielding

The use of ⁵¹Cr as a dietary marker in rats for the determination of ⁵⁹Fe absorbability in terms of mucosal uptake and mucosal transfer of ⁵⁹Fe

Contact Info

Product

Resources

About

Normal iron absorption and decreased red cell iron uptake in the aged

Cited by 6 publications

References 0 publications

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Simultaneous Measurement of 59Fe and 51Cr in Iron Absorption Studies Using a Whole-Body Scanner with Mobile Shielding

The use of 51Cr as a dietary marker in rats for the determination of 59Fe absorbability in terms of mucosal uptake and mucosal transfer of 59Fe

Contact Info

Product

Resources

About

The use of ⁵¹Cr as a dietary marker in rats for the determination of ⁵⁹Fe absorbability in terms of mucosal uptake and mucosal transfer of ⁵⁹Fe