Noradrenaline Release And Sympathetic Nervous System Activity

Esler, Murray; Hasking, Gregory J.; Willett, Ian R.; Leonard, P; Jennings, Garry

doi:10.1097/00004872-198504000-00003

Cited by 156 publications

(92 citation statements)

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“…Some caution is needed, however, since circulating catecholamines reflect not only the production rate of norepinephrine but also its clearance rate from plasma. 14,15 Furthermore, venous norepinephrine levels give no indication of the source of the hormone-whether it be mainly cardiac, renal or skeletal muscle,etc. 14,15 It is entirely possible furthermore that withdrawal of parasympathetic activity might contribute to the haemodynamic abnormalities in pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

Effect of changes in body posture on vasoactive hormones in pre-eclamptic women

et al. 2004

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The aim of this study was to determine the normality or otherwise of neurohormone indices, particularly the sympathetic nervous system, in pre-eclamptic patients and document whether changes in body posture magnify any differences between pre-eclamptic and normal women. We studied 11 women with pre-eclampsia and compared them with 17 matched normotensive pregnant women and eight nonpregnant women. Measurements of arterial pressure, heart rate and neurohormones were carried out with subjects in the left lateral position, then supine, left lateral, with upright posture and finally with assumption of the left lateral position again. Main outcome measures were arterial pressure, heart rate and hormones (plasma norepinephrine, renin activity, natriuretic peptides and endothelin-1). We observed that plasma norepinephrine levels were higher in pre-eclamptic than normotensive pregnant women and this was most obvious in the upright position. Plasma renin activity was likewise higher in pre-eclamptic than normotensive pregnant women, again most obvious with upright posture. Plasma natriuretic peptides and endothelin-1 levels were similar in pre-eclamptics and normotensive pregnant women. These data strengthen the premise that pre-eclampsia is associated with sympathetic overactivity as reflected by plasma norepinephrine levels, most obviously observed in the upright position.

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Section: Discussionmentioning

confidence: 99%

Effect of changes in body posture on vasoactive hormones in pre-eclamptic women

et al. 2004

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“…The sympathetic out flow to all organs is not uniform, and regional, organspecific increases or decreases in sympathetic nervous sys tem activity can occur with different reflexes. 40 In a previous study we found that the normal increase in plasma norepinephrine level after a meal in healthy el derly subjects is not sustained in those with PH.18 In the current study, when BP declined between 30 and 90 min utes after the meal, plasma norepinephrine levels inap propriately decreased to baseline levels. These data sug gest that elderly patients with syncope with PH are unable to maintain activation of the sympathetic nervous sys tem after a meal.…”

Section: Changes In Plasma Norepinephrine Level Cardiac Index Systementioning

confidence: 40%

Postprandial hypotension in elderly patients with unexplained syncope

Jansen¹

1995

Archives of Internal Medicine

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“…In such cases, the required concentration of vital neurotransmitter is regarded as the determining factor [69]. Conditions associated with the sympathetic nervous system such as sympathetic hyper activation occur along with symptoms such as palpitation, anxiety, sweating, alteration in blood pressure, and headache [70,71].…”

Section: Reviewmentioning

confidence: 99%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychobehaviour of the subject. Several neurological disease profiles have been reported with such specific psychobehavioural expression. However, application of behavioural abnormalities as possible disease progress markers has not been considered and emphasised much. Reports suggested that-the subjects, who have already entered into the terminal stage of the disease, used to show cardinal behavioural signs for a specific disease profile. However, psychological expressions are comparatively early expressive. As most of the neurodegenerative disorders are unidirectional and progressive by nature, therapeutic intervention at the right time is essential for attaining the desired outcome. Moreover, early diagnosis can aid in managing the disease progression also. Psychobehavioural analysis could meet the expected outcome of disease diagnosis if implemented properly and timely. In the present review, we have amalgamated the reported behavioural anomalies with the supportive background from neurochemical basis. Further, we have concluded that behaviour centric studies could be a potential diagnostic tool for the early diagnosis of major neurological diseases such as Alzheimer disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Bipolar disorder, Schizophrenia, Impulse control disorder (ICD) and Obsessive-compulsive disorder (OCD).

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Noradrenaline Release And Sympathetic Nervous System Activity

Cited by 156 publications

References 0 publications

Effect of changes in body posture on vasoactive hormones in pre-eclamptic women

Effect of changes in body posture on vasoactive hormones in pre-eclamptic women

Postprandial hypotension in elderly patients with unexplained syncope

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

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