Nonylphenol acts on prostate adenocarcinoma cells via estrogen molecular pathways

Forte, Maurizio; Lorenzo, Mariana Di; Iachetta, Giuseppina; Mita, Damiano Gustavo; Laforgia, Vincenza; Falco, Maria De

doi:10.1016/j.ecoenv.2019.05.035

Cited by 22 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These substances have been studied extensively in humans, nevertheless, much less in the environment. It is known that they can alter the reproductive system, cause Alzheimer’s disease, thyroid problems, obesity and/or cancer (prostate, breast or endometrium cancer), among others ( Heindel et al, 2015 ; Forte et al, 2016 , 2019 ; Braun, 2017 ; Nadal et al, 2017 ; Marotta et al, 2019 ). In natural ecosystems, the reproductive system is also affected, as well as the levels of vitellogenin and hatchability and thus feminization with the consequent threat to the preservation of biodiversity ( Vieira et al, 2020 ; Akhbarizadeh et al, 2021 ; Table 2 ).…”

Section: Impact Of Pharmaceuticals On the Environment And Living Orga...mentioning

confidence: 99%

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

et al. 2022

View full text Add to dashboard Cite

The presence of emerging contaminants in the environment, such as pharmaceuticals, is a growing global concern. The excessive use of medication globally, together with the recalcitrance of pharmaceuticals in traditional wastewater treatment systems, has caused these compounds to present a severe environmental problem. In recent years, the increase in their availability, access and use of drugs has caused concentrations in water bodies to rise substantially. Considered as emerging contaminants, pharmaceuticals represent a challenge in the field of environmental remediation; therefore, alternative add-on systems for traditional wastewater treatment plants are continuously being developed to mitigate their impact and reduce their effects on the environment and human health. In this review, we describe the current status and impact of pharmaceutical compounds as emerging contaminants, focusing on their presence in water bodies, and analyzing the development of bioremediation systems, especially mycoremediation, for the removal of these pharmaceutical compounds with a special focus on fungal technologies.

show abstract

Section: Impact Of Pharmaceuticals On the Environment And Living Orga...mentioning

confidence: 99%

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Due to their affinity to bind to the estrogen receptors (ERs), even if it is lower compared to the endogenous hormone 17-b-estradiol (E2), their mode of action is thought to be mediated by an interaction with ERs [15][16][17][18], thus envisaging agonistic or antagonistic activity on the target tissues [19].…”

Section: Of 14mentioning

confidence: 99%

“…Accumulating evidence reported that the main target is represented by the male and female reproductive systems. In males, this can negatively affect sperm vitality and density and testicular cancer, as well as prostate cancer; in females, the exposure is associated with menstrual cycle alteration, sex ratio imbalance and breast cancer [15,16,[20][21][22].…”

Section: Of 14mentioning

confidence: 99%

Alkyphenol Exposure Alters Steroidogenesis in Male Lizard Podarcis siculus

Lorenzo

Mileo

Laforgia

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

Background: Nonylphenol (NP) and Octylphenol (OP) are persistent and non-biodegradable environmental contaminants classified as endocrine disruptor chemicals (EDCs). These compounds are widely used in several industrial applications and present estrogen-like properties, which have extensively been studied in aquatic organisms. The present study aimed to verify the interference of these compounds alone, and in mixture, on the reproductive cycle of the male terrestrial vertebrate Podarcis siculus, focusing mainly on the steroidogenesis process. Methods: Male lizards have been treated with different injections of both NP and OP alone and in mixture, and evaluation has been carried out using a histological approach. Results: Results obtained showed that both substances are able to alter both testis histology and localization of key steroidogenic enzymes, such as 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β- hydroxysteroid dehydrogenase (17β-HSD) and P450 aromatase. Moreover, OP exerts a preponderant effect, and the P450 aromatase represents the major target of both chemicals. Conclusions: In conclusion, NP and OP inhibit steroidogenesis, which in turn may reduce the reproductive capacity of the specimens.

show abstract

“…Mancozeb also exerts numerous injurious effects related to the function of the thyroid gland (Axelstad et al 2011;Goldner et al 2010). Additionally, several reports suggested a xenoestrogenic activity of alkylphenols (APs), such as Bisphenol A (BPA), NonylPhenol (NP), an OctylPhenol (OP) (Acconcia et al 2017;Forte et al 2016Forte et al , 2019In et al 2015;Liu et al 2017). These substances are largely used in industry to optimize the production of different products, such as herbicides, pesticides, lubricants, plastics, and personal care products (Asimakopoulos et al 2012;Raecker et al 2011).…”

Section: Graphic Abstractmentioning

confidence: 99%

OctylPhenol (OP) Alone and in Combination with NonylPhenol (NP) Alters the Structure and the Function of Thyroid Gland of the Lizard Podarcis siculus

Sciarrillo

Lorenzo

Valiante

et al. 2021

Arch Environ Contam Toxicol

Self Cite

View full text Add to dashboard Cite

Different environmental contaminants disturb the thyroid system at many levels. AlkylPhenols (APs), by-products of microbial degradation of AlkylPhenol Polyethoxylates (APEOs), constitute an important class of Endocrine Disrupting Chemicals (EDCs), the two most often used environmental APs being 4-nonylphenol (4-NP) and 4-tert-octylphenol (4-t-OP). The purpose of the present study was to investigate the effects on the thyroid gland of the bioindicator Podarcis siculus of OP alone and in combination with NP. We used radioimmunoassay to determine their effects on plasma 3,3′,5-triiodo-L-thyronine (T3), 3,3′,5,5′-L-thyroxine (T4), thyroid-stimulating hormone (TSH), and thyrotropin-releasing hormone (TRH) levels in adult male lizards. We also investigated the impacts of AP treatments on hepatic 5′ORD (type II) deiodinase and hepatic content of T3 and T4. After OP and OP + NP administration, TRH levels increased, whereas TSH, T3, and T4 levels decreased. Lizards treated with OP and OP + NP had a higher concentration of T3 in the liver and 5′ORD (type II) activity, whereas T4 concentrations were lower than that observed in the control group. Moreover, histological examination showed that the volume of the thyroid follicles became smaller in treated lizards suggesting that that thyroid follicular epithelial cells were not functionally active following treatment. This data collectively suggest a severe interference with hypothalamus–pituitary–thyroid axis and a systemic imbalance of thyroid hormones. Graphic Abstract

show abstract

Nonylphenol acts on prostate adenocarcinoma cells via estrogen molecular pathways

Cited by 22 publications

References 38 publications

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

Alkyphenol Exposure Alters Steroidogenesis in Male Lizard Podarcis siculus

OctylPhenol (OP) Alone and in Combination with NonylPhenol (NP) Alters the Structure and the Function of Thyroid Gland of the Lizard Podarcis siculus

Contact Info

Product

Resources

About