2015
DOI: 10.1021/cm504572b
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Abstract: One prevention and therapeutic strategy for diseases associated with peptide or protein fibrillation is to inhibit or delay the fibrillation process. Carbon dots (C–Dots) have recently emerged as benign nanoparticles to replace toxic quantum dots and have attracted great attention because of their unique optical properties and potential applications in biological systems. However, the effect of C-Dots on peptide or protein fibrillation has not been explored. In this in vitro study, human insulin was selected a… Show more

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Cited by 168 publications
(164 citation statements)
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References 40 publications
(55 reference statements)
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“…Our experiments demonstrated that these CDs strongly inhibit human insulin fibrillation in a concentration-dependent manner [21]. Increasing the concentration of CDs enhances the inhibiting effect.…”
Section: Discussionmentioning
confidence: 59%
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“…Our experiments demonstrated that these CDs strongly inhibit human insulin fibrillation in a concentration-dependent manner [21]. Increasing the concentration of CDs enhances the inhibiting effect.…”
Section: Discussionmentioning
confidence: 59%
“…On the contrary, the presence of the DHLA-CDs in this study promotes human insulin fibrillation in a concentration-dependent manner. One has to point out that the DHLA-CDs have completely different nature in terms of size, surface property and component from those we reported in Reference [21]. As displayed in Figure 2D and 2E, the size of the DHLA-CDs is much larger (i.e.…”
Section: Discussionmentioning
confidence: 62%
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