Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic

Abstract

Both NSAIDs and opioids can provide effective analgesia in acute renal colic. Opioids are associated with a higher incidence of adverse events, particularly vomiting. Given the high rate of vomiting associated with the use of opioids, particularly pethidine, and the greater likelihood of requiring further analgesia, we recommend that if an opioid is to be used it should not be pethidine.

Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials

“…It should be highlighted that combination therapy was also an optimal choice for patients with uncontrolled pain after receiving NASIDs. In addition, our analysis also found opioids induced more vomiting events and nonspecific adverse events, as has been reported in other studies (Holdgate and Pollock, 2005; Pathan et al, 2016). Then, our analysis compared five interventions based on routes of administration to figure out the impact of routes on treatment of acute renal colic in the second stage.…”

Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials

“…It should be highlighted that combination therapy was also an optimal choice for patients with uncontrolled pain after receiving NASIDs. In addition, our analysis also found opioids induced more vomiting events and nonspecific adverse events, as has been reported in other studies (Holdgate and Pollock, 2005; Pathan et al, 2016). Then, our analysis compared five interventions based on routes of administration to figure out the impact of routes on treatment of acute renal colic in the second stage.…”

Salbutamol for analgesia in renal colic: a prospective, randomised, placebo-controlled phase II trial

“…The clinical problem driving the development of this trial was a recognition that current analgesic regimens for renal colic are frequently ineffective, with many patients not achieving adequate pain relief and requiring rescue analgesia. 13 The median baseline pain score for both trial groups was 67 mm despite participants having received standard analgesics; this is consistent with previous studies. Furthermore, most participants reported ongoing pain throughout the trial period.…”

Paracetamol, ketorolac, and morphine in post‐trauma headache in emergency department: A double blind randomized clinical trial

“…They showed that the efficacy and side effects of paracetamol were lower than morphine 29 . Holdgate and Pollock 30 indicated that NSAIDs are more effective and less complicated than morphine in controlling renal colic, which confirms the results of our study.…”

Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials

“…It should be highlighted that combination therapy was also an optimal choice for patients with uncontrolled pain after receiving NASIDs. In addition, our analysis also found opioids induced more vomiting events and nonspecific adverse events, as has been reported in other studies (Holdgate and Pollock, 2005; Pathan et al, 2016). Then, our analysis compared five interventions based on routes of administration to figure out the impact of routes on treatment of acute renal colic in the second stage.…”

Salbutamol for analgesia in renal colic: a prospective, randomised, placebo-controlled phase II trial

“…The clinical problem driving the development of this trial was a recognition that current analgesic regimens for renal colic are frequently ineffective, with many patients not achieving adequate pain relief and requiring rescue analgesia. 13 The median baseline pain score for both trial groups was 67 mm despite participants having received standard analgesics; this is consistent with previous studies. Furthermore, most participants reported ongoing pain throughout the trial period.…”

Paracetamol, ketorolac, and morphine in post‐trauma headache in emergency department: A double blind randomized clinical trial

“…They showed that the efficacy and side effects of paracetamol were lower than morphine 29 . Holdgate and Pollock 30 indicated that NSAIDs are more effective and less complicated than morphine in controlling renal colic, which confirms the results of our study.…”

Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials

“…It should be highlighted that combination therapy was also an optimal choice for patients with uncontrolled pain after receiving NASIDs. In addition, our analysis also found opioids induced more vomiting events and nonspecific adverse events, as has been reported in other studies (Holdgate and Pollock, 2005; Pathan et al, 2016). Then, our analysis compared five interventions based on routes of administration to figure out the impact of routes on treatment of acute renal colic in the second stage.…”

Salbutamol for analgesia in renal colic: a prospective, randomised, placebo-controlled phase II trial

“…The clinical problem driving the development of this trial was a recognition that current analgesic regimens for renal colic are frequently ineffective, with many patients not achieving adequate pain relief and requiring rescue analgesia. 13 The median baseline pain score for both trial groups was 67 mm despite participants having received standard analgesics; this is consistent with previous studies. Furthermore, most participants reported ongoing pain throughout the trial period.…”

Paracetamol, ketorolac, and morphine in post‐trauma headache in emergency department: A double blind randomized clinical trial

“…They showed that the efficacy and side effects of paracetamol were lower than morphine 29 . Holdgate and Pollock 30 indicated that NSAIDs are more effective and less complicated than morphine in controlling renal colic, which confirms the results of our study.…”