Nonmotor Symptoms in Essential Tremor and Other Tremor Disorders

Fois, Alessandro F.; Briceño, Hugo Morales; Fung, Victor S.C.

doi:10.1016/bs.irn.2017.05.010

Cited by 7 publications

(2 citation statements)

References 109 publications

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“…ET has traditionally been characterized by its motor features [2]. However, recent evidence has shown that ET is a multidimensional disorder with non-motor (e.g., cognitive) features as well [3]. Indeed, patients with ET appear to have an increased odds or risk of developing mild cognitive impairment (MCI) and dementia [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor

Iglesias-Hernandez

Chapman

Radler

et al. 2021

Tremor and Other Hyperkinetic Movements

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Background: Patients with essential tremor (ET) have an increased risk of cognitive impairment, yet little is known about the predictors of cognitive decline in these patients. Exposures to infectious agents throughout the lifespan may impact the later development of cognitive impairment. For example, high Infection exposure has been associated with lower cognitive performance in Alzheimer's and Parkinson's disease. However, this predictor has not been examined in ET.Objectives: To determine whether a higher baseline infection burden is associated with worse cognitive performance at baseline and greater cognitive decline over time in an ET cohort.Method/Design: 160 elderly non-demented ET participants (80.0 ± 9.5 years) underwent an extensive cognitive evaluation at three time points. At baseline, participants completed an infection burden questionnaire (t-IBQ) that elicited information on previous exposure to infectious agents and number of episodes per disease. Analysis of covariance and generalized estimated equations (GEEs) were used.Results: Overall, infection burden was not associated baseline cognitive performance. Adjusted GEE models for repeated measures yielded a significant time interaction between moderate infection burden at baseline and better performance in the attention domain over time (p = 0.013). Previous history of rubella was associated with faster rate of decline in visuospatial performance (p = 0.046). Conclusion:The data were mixed. Moderate self-reported infection burden was associated with better attention performance over time. Self-reported history of rubella infection was related to lower visuospatial performance over time in this cohort. Follow-up studies with additional design elements would be of value.

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Section: Introductionmentioning

confidence: 99%

Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor

Iglesias-Hernandez

Chapman

Radler

et al. 2021

Tremor and Other Hyperkinetic Movements

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“…Persons with ET also commonly exhibit axial motor symptoms, notably midline tremor 2 (e.g., tremor of the head, jaw, voice, or trunk) and gait ataxia 3–5 in addition to occasional nonmotor symptoms. 6…”

Section: Introductionmentioning

confidence: 99%

Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor

Higuchi

Roemmich

Martínez-Ramírez

et al. 2019

Tremor and Other Hyperkinetic Movements

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BackgroundEssential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established.MethodsWe investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus.ResultsStimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement.DiscussionThese findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.

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