Nonmelanoma skin cancers and infection with the human immunodeficiency virus

Lobo, D. V.

doi:10.1001/archderm.128.5.623

Cited by 28 publications

(22 citation statements)

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“…There is a 3-to 5-fold increased risk of developing nonmelanoma skin cancers (SCCs and BCCs) with HIV infection [51] although risk factors, such as sun exposure and fair skin type, are the same in both HIV-infected and immunocompetent populations [52,53]. The clinical characteristics of BCCs do not vary significantly in HIVinfected individuals, and therefore their management does not differ from immunocompetent patients [52].…”

Section: Neoplastic Skin Diseasesmentioning

confidence: 99%

Cutaneous Markers of HIV Infection and Progression

Ameen¹

2010

CHR

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Skin and mucosal diseases can be the first manifestation of asymptomatic HIV infection, may indicate advancing immunodeficiency, or may represent systemic opportunistic infections or neoplasms. Mucocutaneous diseases are highly prevalent in the HIV-infected population and multiple pathologies are common particularly with advanced immunosuppression. The dominant HIV-associated skin diseases are infectious and inflammatory and they can cause significant morbidity. Although skin cancers are less common their prognosis is often worse. Clinical presentations are often atypical and may vary depending on the level of immunosuppression. Managing skin disease in the context of advanced immunosuppression is challenging and they often respond poorly to conventional therapies. This improves with the commencement of antiretrovirals (ARVs) and immune restoration. Despite the significant decline in HIV-related skin diseases with ARVs, the drugs themselves have brought with them a range of other skin-associated problems: adverse effects, an increased risk of drug reactions, and immune reconstitution-associated skin diseases. Therefore, the burden of skin disease remains high even in the era ARVs and the aim of this review is to equip physicians managing HIV-infected patients with knowledge of the spectrum of skin disorders associated with HIV-related immunosuppression.

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Section: Neoplastic Skin Diseasesmentioning

confidence: 99%

Cutaneous Markers of HIV Infection and Progression

Ameen¹

2010

CHR

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“…116,117 BCCs generally appear on the trunk, and SCCs on the head and neck. BCCs have been reported to be 11.4 times more common in HIV-infected hemophiliac patients than in the general population.…”

Section: Squamous and Basal Cell Carcinomamentioning

confidence: 99%

“…The most common clinical and histologic presentation of BCC is the superficial type, which tends to present on the trunk and may be multiple. 106,117 In contrast, other immunosuppressed states have a statistically significant increase in infiltrative-type BCC. 118 More aggressive BCCs have been reported in HIV patients, including metastatic BCC, 119 multiple infundibulocystic BCC, 120 and aggressive morpheaform type in a scar.…”

Section: Squamous and Basal Cell Carcinomamentioning

confidence: 99%

“…HPV in these cases generally is of a highrisk 116,[124][125][126] or an unusual HPV type. 117,127 Infection with these unusual HPV types is more common in HIV disease. 125 A recent report about nail unit SCC recommended that all verruca on the nail unit should be considered a possible SCC if the patient has a history of genital warts, dysplasia, or immunosuppression.…”

Section: Squamous and Basal Cell Carcinomamentioning

confidence: 99%

“…117 We recommend use of standard treatment protocols for treatment of BCC and close follow-up. Use of imiquimod for BCC in this population has not been studied.…”

Section: Treatment and Follow-upmentioning

confidence: 99%

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