Nonmelanoma skin cancer mortality. A population-based study

Recurrent Basal Cell Carcinoma After Incomplete Resection

“…16 Mortality from nonmelanoma skin cancer was strongly concentrated in the elderly, with ageadjusted male-female mortality being 3.9 for squamous cell carcinoma and 2.3 for BCC. 17 Thus, men had a 40% greater case fatality rate than women did for BCC and squamous cell carcinoma. 17 Within the same greater Chicago referral area represented in this study, another group 18 reported a greater mean tumor thickness of invasive melanoma in the elderly (Ն70 years).…”

“…17 Thus, men had a 40% greater case fatality rate than women did for BCC and squamous cell carcinoma. 17 Within the same greater Chicago referral area represented in this study, another group 18 reported a greater mean tumor thickness of invasive melanoma in the elderly (Ն70 years). In the United States, the age-specific mortality for melanoma is greatest for elderly men (Ն70 years).…”

Keratinocyte Carcinoma

“…2 In addition, an estimated 1,000 to 2,000 deaths result each year from KC in the United States, with population-based case-fatality rates of approximately 0.05% and 0.7% for basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), respectively. 3 In contrast, melanoma occurs less frequently, but more commonly causes death, with 54,200 new cases and 7,600 deaths estimated for 2003. 4 Nevertheless, melanoma accounts for a minority of skin cancer deaths among white persons older than 85 years and among black persons.…”

“…A study of confirmed KC deaths occurring in Rhode Island from 1979 through 1987 found that 47% of fatal primary SCCs were located on the ear, although only 10% of incident SCCs were in this location. 3 Other factors indicating a greater risk for metastasis (and local recurrence) include association with a scar, sinus tract, or chronic ulcer; size greater than 2 cm; depth greater than 4 mm; poor differentiation or perineural invasion histologically; and recurrent disease. 34 SCC of the anogenital region also has a higher metastatic rate.…”

Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

“…Type VII collagen interacts with proteins localised close to the basement membrane; laminin 332 (Ln332) and type IV collagen (Chen et al, 1997;Rousselle et al, 1997), as well banded collagen I that are localised in the dermis (Villone et al, 2008), providing strong adhesive connection between these two compartments. Over 90% of RDEB patients develop metastatic cSCC by age 55, a figure significantly higher than that in the general population where metastatic disease is relatively rare (Weinstock et al, 1991;Miller and Weinstock, 1994;Fine et al, 2009). The underlying molecular mechanism driving predisposition to develop aggressive cSCC in RDEB is not fully understood (South and O'Toole, 2010) although recent data from our laboratory show that tumour microenvironment, in particular the altered composition of extracellular matrix in RDEB, can promote tumours (Ng et al, 2012).…”