volume 83, issue 11, P1923-1928 2015
DOI: 10.1002/prot.24916
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Abstract: We examine the utility of informatic-based methods in computational protein biophysics. To do so, we use newly developed metric functions to define completely independent sequence and structure spaces for a large database of proteins. By investigating the relationship between these spaces, we demonstrate quantitatively the limits of knowledge-based correlation between the sequences and structures of proteins. It is shown that there are well-defined, nonlinear regions of protein space in which dissimilar struc…

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