Noninvasive real-time laser Doppler flowmetry in perfusion regions and larger vessels

Three-Dimensional Highly Sensitive Diffusion Reflection-Based Imaging Method for the in Vivo Localization of Atherosclerosis Plaques Following Gold Nanorods Accumulation

“…Diffusion reflection (DR) spectroscopy is a simple, safe, and easy-to-apply diagnostic technique that has the potential to provide important morphological information regarding biological tissues without requiring high radiation intensities or high penetration depth. − On the basis of this technique, a pair of source and detector fibers placed along the tissue surface, separated by a distance origin from few millimeters to few centimeters, to enable the DR collection . Previous research studies have suggested that DR measurements can serve for functional diagnosis and therapeutic monitoring of cancer diseases. − This includes, for example, dynamic near-infrared (NIR) technique, denoted diffuse correlation spectroscopy , and diffuse wave spectroscopy. , Still, similar to other NIR spectroscopies, these methods use natural endogenous tumor-to-normal contrasts available in tissues, such as oxy-deoxy and total hemoglobin, water, lipids, and blood, and therefore suffer from relatively low signal-to-noise ratio (SNR) because of the high scattering properties of the tissue in the optics region. Our previous works have suggested an improved SNR of the diffusion-based spectroscopy by the insertion of biocompatible contrast agents into the tissue, to increase the optical contrast between the site of interest and its surrounding .…”

On Phantom Experiments of the Photon Migration Model in Tissues

“…Despite the complexity of light path through tissues, many applications were and are being developed based on tissue irradiation for clinical or diagnostic purposes [8][9][10]. Therefore, many researches present the influence of tissues' optical parameters on the light path inside.…”