Noninvasive methods for haemoglobin screening in prospective blood donors

Belardinelli, A.; Benni, Monica; Tazzari, Pl; Pagliaro, Pasqualepaolo

doi:10.1111/vox.12033

Cited by 43 publications

(66 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Belardinelli et al (2013) found that the Pronto-7 had a similar bias of -0.53 g/dL, SDD of 1.04 and 95% limits of agreement from -2.57 to 1.51 when compared to the Beckman Coulter Cell Counter at sea level. That study also showed the same trend bias that we observed in our study.…”

Section: Discussionmentioning

confidence: 95%

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Vyas

Danz

Gilman

et al. 2015

High Altitude Medicine & Biology

View full text Add to dashboard Cite

. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude. High Alt Med Biol 16:162-168, 2015.-Globally, over 140 million people are at risk of developing chronic mountain sickness, a common maladaptation to life at high altitude ( > 2500 meters above sea level). The diagnosis is contingent upon the identification of excessive erythrocytosis (EE). Current best practices to identify EE require a venous blood draw, which is cumbersome for large-scale surveillance. We evaluated two point-of-care biomarkers to screen for EE: noninvasive spot-check tests of total hemoglobin and oxyhemoglobin saturation (Pronto-7, Masimo Corporation). We conducted paired evaluations of total serum hemoglobin from a venous blood draw and noninvasive, spot-check testing of total hemoglobin and oxyhemoglobin saturation with the Pronto-7 in 382 adults aged ‡ 35 years living in Puno, Peru (3825 meters above sea level). We used the Bland-Altman method to measure agreement between the noninvasive hemoglobin assessment and the gold standard lab hemoglobin analyzer. Mean age was 58.8 years and 47% were male. The Pronto-7 test was unsuccessful in 21 (5%) participants. Limits of agreement between total hemoglobin measured via venous blood draw and the noninvasive, spot-check test ranged from -2.8 g/dL (95% CI -3.0 to -2.5) to 2.5 g/dL (95% CI 2.2 to 2.7), with a bias of -0.2 g/dL (95% CI -0.3 to -0.02) for the difference between total hemoglobin and noninvasive hemoglobin concentrations. Overall, the noninvasive spot-check test of total hemoglobin had a better area under the receiver operating characteristic curve compared to oxyhemoglobin saturation for the identification of EE as measured by a gold standard laboratory hemoglobin analyzer (0.96 vs. 0.82; p < 0.001). Best cut-off values to screen for EE with the Pronto 7 were ‡ 19.9 g/dL in males and ‡ 17.5 g/dL in females. At these cutpoints, sensitivity and specificity were both 92% and 89% for males and females, respectively. A noninvasive, spot-check test of total hemoglobin had low bias and high discrimination for the detection of EE in high altitude Peru, and may be a useful point-of-care tool for large-scale surveillance in high-altitude settings.

show abstract

Section: Discussionmentioning

confidence: 95%

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Vyas

Danz

Gilman

et al. 2015

High Altitude Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…An important issue in the measurement of capillary hemoglobin seems to be the pre-analytical variability of sampling related not only to anatomical differences at finger pulp circulation but also difference between venous and capillary blood has to be taken into account. 18) Although NBM 200 had the highest specificity, having a very low sensitivity, more than 80% of donors who did not satisfy the Hb criteria would have been accepted for blood donation (Table 3) Hb measurement remains a conflictive issue in routine donor acceptance procedures and these devices needs to be improved prior to apply in the blood…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Two Noninvasive Hemoglobin Testing Devices

Kim

Choi

Yang

et al. 2015

KJBT

View full text Add to dashboard Cite

Background: Determination of the hemoglobin (Hb) levels of prospective blood donors has been performed on capillary blood obtained by finger prick using a gravimetric CuSO 4 method. Noninvasive Hb testing devices based on pulse oximetry technology have recently been developed. This study was conducted to evaluate the performance of two noninvasive Hb testing devices, NBM 200 and Pronto-7 as a predonation Hb screening test. Methods: Hb levels of 993 blood donors (727 males, 266 females) were measured using five methods: two noninvasive methods, CuSO 4 method, HemoCue, and hematology analyzer (Sysmex KX-21N). The hematology analyzer was considered as the reference method. Results: Compared with Hb levels of the hematology analyzer, the bias was 0.7 g/dL for NBM 200, 0.1 g/dL for Prtonto-7, and 0.4 g/dL for HemoCue. The intraclass correlation coefficients of Hb measurements compared to the hematology analyzer were 0.57 (95% CI: 0.25∼0.73) for NBM 200, 0.73 (95% CI: 0.69∼0.75) for Pronto-7, and 0.87 (95% CI: 0.69∼0.93) for HemoCue. The ability to detect Hb ＜12.5 g/dL and ≥12.5 g/dL was 16.4% and 99.2% for NBM 200, 55.8% and 95.9% for Pronto-7, 60.0% and 98.6% for HemoCue and 81.8% and 95.2% for the CuSO 4 method, respectively. Conclusion: Unsatisfactory results were obtained using the noninvasive Hb testing devices for a predonation Hb screening test, although they have the apparent advantage of reducing pain and stress in donors thereby increasing donor satisfaction. However, for application in the blood donation setting, performance of these devices should be improved. (Korean J Blood Transfus 2015;26:273-281 Materials and MethodsAll (Table 3).

show abstract

“…Kim et al [35] evaluated the usefulness of the NBM-200 for blood donor screening and concluded that wrong decisions could occur when deciding eligibility for blood donation using this device. Another reports of blood donor screening using the NBM-200 are available [36,37]. Pinto et al compared performance of fingerstick sampling and NBM-200, and significantly lower level of percentage error was found in NBM-200 compared to reference value (tHb).…”

Section: Other Situationsmentioning

confidence: 99%

Current Use of Noninvasive Hemoglobin Monitoring in Anesthesia

Lee

Park

Kim

2014

Curr Anesthesiol Rep

View full text Add to dashboard Cite

Modern technology enables clinicians to assess hemoglobin levels noninvasively and continuously. Some instruments also provide concentrations of other types of hemoglobin, such as methemoglobin and carboxyhemoglobin. Such information obtained immediately and noninvasively can be helpful in the management of critically ill patients or those undergoing surgery with bleeding. However, the accuracy of noninvasive hemoglobin measurements should be evaluated before clinical application, particularly for transfusion decisions. Clinicians should be aware of the performance of continuous noninvasive hemoglobin monitoring devices during anesthesia and of the various factors that influence their accuracy. This review considers the accuracy of current continuous noninvasive hemoglobin monitoring and its clinical use.

show abstract

Noninvasive methods for haemoglobin screening in prospective blood donors

Cited by 43 publications

References 17 publications

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Evaluation of Two Noninvasive Hemoglobin Testing Devices

Current Use of Noninvasive Hemoglobin Monitoring in Anesthesia

Contact Info

Product

Resources

About