Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI

Bashir, Adil; Gray, Martha L.; Hartke, James R.; Burstein, Deborah

doi:10.1002/(sici)1522-2594(199905)41:5<857::aid-mrm1>3.3.co;2-5

Cited by 221 publications

(337 citation statements)

References 2 publications

Supporting

Mentioning

320

Contrasting

Unclassified

Order By: Relevance

“…The first T1 Gd images were obtained with a twodimensional (2D) T1-weighted inversion recovery (IR) sequence [10,35]. Advantages of this technique are the widespread availability of the sequence and proper contrast properties.…”

Section: Dgemric Techniquementioning

confidence: 99%

Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

et al. 2015

View full text Add to dashboard Cite

Accurate assessment of early hip joint cartilage alterations may help optimize patient selection and follow-up of hip joint preservation surgery. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. The purpose of this review is to outline the current status of dGEMRIC in the assessment of hip joint cartilage. A literature search was performed with PubMed, using the terms "cartilage, osteoarthritis, hip joint, MRI, and dGEMRIC", considering all levels of studies. This review revealed that dGEMRIC can be reliably used in the evaluation of early stage cartilage pathology in various hip joint disorders. Modifications in the technique, such as the operation of three-dimensional imaging and dGEMRIC after intra-articular contrast medium administration, have expanded the range of application. Notably, the studies differ considerably in patient selection and technical prerequisites. Furthermore, there is a need for multicenter prospective studies with the required technical conditions in place to establish outcome based dGEMRIC data to obtain, in conjunction with clinical data, reliable threshold values for normal and abnormal cartilage, and for hips that may benefit from conservative or surgical treatment.

show abstract

Section: Dgemric Techniquementioning

confidence: 99%

Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…An increased accumulation of contrast agent due to a depletion of GAG in cartilage will lead to decreased T1. T1 relaxation enhanced by delayed administration of Gd-DTPA 2− , the dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) technique, is currently the most widely used method for analyzing proteoglycan depletion in articular cartilage and has provided valuable results in vitro and in vivo [95][96][97][98][99]. Post-contrast T1 mapping is usually performed approximately 90 min after intravenous injection of Gd-DTPA 2− , to allow sufficient time for the contrast agent (Gd) to diffuse into the cartilage layer before the images are acquired.…”

Section: Feasibility In Clinical Routine and Diagnostic Valuementioning

confidence: 99%

MR imaging of cartilage and its repair in the knee - a review

et al. 2009

View full text Add to dashboard Cite

Chondral injuries are common lesions of the knee joint, and many patients could benefit from cartilage repair. Widespread cartilage repair techniques require sophisticated noninvasive follow-up using MRI. In addition to the precise morphological assessment of this area of cartilage repair, the cartilage's biochemical constitution can be determined using biochemical MRI techniques. The combination of the clinical outcome after cartilage repair together with the morphological and biochemical description of the cartilage repair tissue as well as the surrounding cartilage can lead to an optimal follow-up evaluation. The present article on MR imaging techniques of cartilage repair focuses on morphological description and scoring using techniques from conventional 2D through advanced isotropic 3D MRI sequences. Furthermore the ultrastructure of the repair tissue and the surrounding cartilage is evaluated in-vivo by biochemical T1-delayed gadolinium enhanced MRI of cartilage (dGEMRIC), T2 relaxation, and diffusion-weighted imaging techniques.

show abstract

“…The only modifications on T1-weighted sequences and profiles that were noted for the 13-year-old animal were observed concomitant with local surface abnormalities (fibrillations and clefts). Biochemical cartilage structure can only be visualized with contrast agents (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…The exploration of human cartilage is difficult, since only cadaveric specimens or osteoarthritic specimens obtained from surgery can be studied for histologic and biochemical correlations. Most of the available work has been performed experimentally, using MR-specific tools such as cartography, diffusion imaging, or contrast agents (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). Such analytic approaches are of the greatest importance for the understanding of MRI.…”

mentioning

confidence: 99%

Structural evaluation of articular cartilage: Potential contribution of magnetic resonance techniques used in clinical practice

Olivier

Lœuille

Watrin

et al. 2001

Arthritis & Rheumatism

View full text Add to dashboard Cite

Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI

Cited by 221 publications

References 2 publications

Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

MR imaging of cartilage and its repair in the knee - a review

Structural evaluation of articular cartilage: Potential contribution of magnetic resonance techniques used in clinical practice

Contact Info

Product

Resources

About