Noncovalent reversible binding-enabled facile fabrication of leak-free PDMS microfluidic devices without plasma treatment for convenient cell loading and retrieval

Jiang, Bin; White, Alisa; Ou, Wenquan; Belleghem, Sarah Van; Stewart, Stanford J.; Shamul, James G.; Rahaman, Shaik O.; Fisher, John P.; He, Xiaoming

doi:10.1016/j.bioactmat.2022.02.031

Cited by 8 publications

(6 citation statements)

References 78 publications

(92 reference statements)

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“…Synthetic polymers are ubiquitous materials used in a wide variety of applications because of their structural and mechanical properties [ 67 ]. The application of polymers as a discontinuous dielectric structure in wearable devices offers a wide range of applications in health monitoring and medical fields [ 27 , 68 , 69 , 70 ]. The rapid development of porous polymers in the last few years has been attributed to the continuous development of modern organic synthesis, advanced polymerization techniques and nanotechnology [ 71 ].…”

Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, the physical effects of microfluid flow in porous media and their related physical models are discussed. Finally, the state-of-the-art porous microfluidic chips and their applications in biomedicine are summarized, and we present the current problems and future directions in this field.

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Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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“…These functional groups alter the surface characteristics of PDMS, converting it from hydrophobic to hydrophilic. However, it is important to note that, on one hand, plasma-treated surfaces exhibit a recovery of hydrophobicity within minutes of exposure [ 49 ], particularly when subjected to bonding and heat treatment [ 50 ]. On the other hand, prolonged plasma treatments can cause undesirable surface cracks that compromise the integrity of the device [ 48 , 51 , 52 ].…”

Section: Oxygen Plasma Treatmentmentioning

confidence: 99%

A Review of Methods to Modify the PDMS Surface Wettability and Their Applications

Neves,

Afonso,

Nobrega

et al. 2024

Micromachines

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Polydimethylsiloxane (PDMS) has attracted great attention in various fields due to its excellent properties, but its inherent hydrophobicity presents challenges in many applications that require controlled wettability. The purpose of this review is to provide a comprehensive overview of some key strategies for modifying the wettability of PDMS surfaces by providing the main traditional methods for this modification and the results of altering the contact angle and other characteristics associated with this property. Four main technologies are discussed, namely, oxygen plasma treatment, surfactant addition, UV-ozone treatment, and the incorporation of nanomaterials, as these traditional methods are commonly selected due to the greater availability of information, their lower complexity compared to the new techniques, and the lower cost associated with them. Oxygen plasma treatment is a widely used method for improving the hydrophilicity of PDMS surfaces by introducing polar functional groups through oxidation reactions. The addition of surfactants provides a versatile method for altering the wettability of PDMS, where the selection and concentration of the surfactant play an important role in achieving the desired surface properties. UV-ozone treatment is an effective method for increasing the surface energy of PDMS, inducing oxidation, and generating hydrophilic functional groups. Furthermore, the incorporation of nanomaterials into PDMS matrices represents a promising route for modifying wettability, providing adjustable surface properties through controlled dispersion and interfacial interactions. The synergistic effect of nanomaterials, such as nanoparticles and nanotubes, helps to improve wetting behaviour and surface energy. The present review discusses recent advances of each technique and highlights their underlying mechanisms, advantages, and limitations. Additionally, promising trends and future prospects for surface modification of PDMS are discussed, and the importance of tailoring wettability for applications ranging from microfluidics to biomedical devices is highlighted. Traditional methods are often chosen to modify the wettability of the PDMS surface because they have more information available in the literature, are less complex than new techniques, and are also less expensive.

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“…The most developed microfluidic devices are PDMS channels or PDMS-based multifunctional platforms ( Figure 2 b–d). PDMS has high flexibility and chemical and thermal stability and is biocompatible with biological and medical applications [ 70 , 71 ]. The frequently used geometries are the T-connection ( Figure 2 b) and the cross-connection of four cross channels ( Figure 2 c).…”

Section: Systems For Microfluidicsmentioning

confidence: 99%

Recent Trends of Microfluidics in Food Science and Technology: Fabrications and Applications

Pang

et al. 2022

Foods

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The development of novel materials with microstructures is now a trend in food science and technology. These microscale materials may be applied across all steps in food manufacturing, from raw materials to the final food products, as well as in the packaging, transport, and storage processes. Microfluidics is an advanced technology for controlling fluids in a microscale channel (1~100 μm), which integrates engineering, physics, chemistry, nanotechnology, etc. This technology allows unit operations to occur in devices that are closer in size to the expected structural elements. Therefore, microfluidics is considered a promising technology to develop micro/nanostructures for delivery purposes to improve the quality and safety of foods. This review concentrates on the recent developments of microfluidic systems and their novel applications in food science and technology, including microfibers/films via microfluidic spinning technology for food packaging, droplet microfluidics for food micro-/nanoemulsifications and encapsulations, etc.

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Noncovalent reversible binding-enabled facile fabrication of leak-free PDMS microfluidic devices without plasma treatment for convenient cell loading and retrieval

Cited by 8 publications

References 78 publications

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

A Review of Methods to Modify the PDMS Surface Wettability and Their Applications

Recent Trends of Microfluidics in Food Science and Technology: Fabrications and Applications

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