The RAG proteins are comprised of core endonuclease domains and non-core regions that modulate endonuclease activity. Mutation or deletion of non-core RAG regions in humans causes immunodeficiency and altered TCR repertoire, and mice expressing core but not full-length Rag1 (Rag1C/C) or Rag2 (Rag2C/C) exhibit lymphopenia, reflecting impaired V(D)J recombination and lymphocyte development. Rag1C/C mice display reduced D-to-J and V-to-DJ rearrangements of TCRβ and IgH loci, while Rag2C/C mice show decreased V-t…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.