Cell Reports volume 4, issue 5, P996-1009 2013 DOI: 10.1016/j.celrep.2013.07.045 View full text
Lisa M. Kennedy, Steven C.D.L. Pham, Alla Grishok

Abstract: SUMMARY Neuronal migration is essential for nervous system development in all organisms and is regulated in the nematode, C. elegans, by signaling pathways that are conserved in humans. Here, we demonstrate that the Insulin/IGF-1-PI3K signaling pathway modulates the activity of the DAF-16/FOXO transcription factor to promote the anterior migrations of the hermaphrodite-specific neurons (HSNs) during embryogenesis of C. elegans. When signaling is reduced, DAF-16 is activated and promotes migration, conversely,…

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