“…Composite synthetic/natural matrix-covered stent-grafts may be promising for prolonging stent-graft patency.Synthetic vascular grafts are widely used in surgical and/or minimally invasive interventional therapeutic procedure to treat vascular diseases, such as coarctation of the aorta, aneurysm, arteriovenous fistula, dissection, iatrogenic vascular perforation, traumatic injury, and hemodialysis access 1,2 . Commercially available synthetic stent-grafts composed of expanded polytetrafluoroethylene (e-PTFE), polyethylene terephthalate (PET) and polyurethane (PU) are characterized by poor endothelialization, high modulus, and low compliance, leading to thrombosis and intimal hyperplasia [3][4][5] . Therefore, rapid endothelialization, good mechanical properties, thromboresistivity and biocompatibility are key to preserving the long-term patency of stent-grafts 6,7 .…”