Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Abstract

Objective-To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Methods and Results-A total of 8632 participants aged ≥40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30.0% in the total population, with 30.3% in men and 29.9% in women, respectively. Subjects with NAFLD had remarkably higher CIMT and ba-PWV compared with those without NAFLD (0.594±0.105 mm versus 0.578±0.109 mm, P<0.0001; 1665±424 cm/s versus 1558±430 cm/s, P<0.0001). Subjects with both NAFLD and metabolic syndrome had significantly higher CIMT and ba-PWV compared with those with neither or either of these 2 diseases after adjustment for age and sex (all P<0.05). Logistic regressions also revealed that NAFLD conferred 35% and 30% increased odds ratios of elevated CIMT and ba-PWV, independent of conventional risk factors and the presence of metabolic syndrome. Key Words: atherosclerosis ◼ brachial-ankle pulse wave velocity ◼ carotid intima-media thickness ◼ metabolic syndrome ◼ nonalcoholic fatty liver disease Conclusion-NAFLD

Association of Micro and Macrovascular Complications with Fatty Liver in Patients with Type 2 Diabetes Mellitus

“…[18][19][20] In addition, fatty liver and CAD share common risk factors like diabetes, obesity, dyslipidemia, hypertension etc. Also, carotid Doppler studies revealed higher intima media thickness in fatty liver patients which confirms the role of atherosclerosis causing similar plaques in coronary vessels and IHD [21] . In our study, the prevalence of nephropathy is slightly higher in the FL group but statically insignificant.…”

The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels

“…Several studies have documented an association between NAFLD and increased risk of cardiovascular morbidity [20][21][22][23][24]. The association between ALT concentration and cardiovascular disease has also been well documented [12,13,25].…”

Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population

“…A total of 10,569 inhabitants were invited to participate in the survey. Among them, 10,375 residents signed the consent form and agreed to take part in the following detailed examination, with a participation rate of 98.2% ( 13,14 ). From these participants, we sequentially excluded subjects who met the following criteria: 1 ) those with missing data on their serum Lp(a) concentrations (n = 16) and/or fasting plasma glucose (FPG) and/or 2 h 75 g oral glucose tolerance test (OGTT) plasma glucose (2 hPG) levels and/or fasting serum insulin (FSI) levels (n = 36); 2 ) those with medical history of self-reported malignant tumors (n = 4); and 3 ) those with serious hepatic or renal dysfunction (n = 197).…”