Nonalcoholic Fatty Liver Disease in Patients With Coronary Disease From a Brazil Northeast Area

Vilar, Consuelo P.; Cotrim, Helma Pinchemel; Florentino, Gesira Soares Assis; Bragagnoli, Gérson; Schwingel, Paulo Adriano; Barreto, Cibelle P.V.

doi:10.1590/s0004-28032015000200007

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Brouwers et al suggested that plasma lipids act as the major mediators in the relationship between NAFLD and CVD [3]. The characteristics of subjects in this study showed that NAFLD patients possess the higher levers of BMI, AST, ALT, TG, LDL, GGT, and decreased level of HDL compare to health controls, that is consistent with the changes of serum lipids pro les in patients with NAFLD in previous studies [32,[35][36][37]. In the overall series in this study, we found that AGT rs2493132 T allele carriers were likely to possess the higher serum TC and LDL levels compared to the non-carriers.…”

Section: Discussionsupporting

confidence: 89%

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Dong

Zhang

et al. 2020

Preprint

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Background: Previous studies proved that AGT gene polymorphisms were associated with the serum lipids metabolism; however, it is not clear whether AGT rs2493132 increases the risk of NAFLD and CAD. This study was designed to investigate the relationship between AGT rs2493132 gene polymorphism and the developing risk of NAFLD and CAD in Chinese Han population.Methods: A total of 142 NAFLD patients, 109 NAFLD + CAD patients, and 246 health controls were included in this study. PCR method was used to measure AGT genotype. The anthropometric and clinical data were measured in clinical laboratory department of Qingdao Municipal Hospital. Statistical analyzes were conducted using the SPSS statistical software, version 21.0. Results: The AGT rs2493132 CT + TT genotype was an important risk factor for CAD in patients with NAFLD (OR = 1.785; 95%CI: 1.061-3.003; P = 0.029), and the risk of CAD in patients with NAFLD was still marked after adjusted for gender, age, and BMI (OR = 4.718; 95%CI: 1.502-14.824; P = 0.008). The T allele of AGT rs2493132 also significantly increased the risk of CAD in NAFLD patients (OR = 2.436; 95% CI: 1.184-5.011, P = 0.016) after adjusted for age, gender, and BMI. In addition, AGT rs2493132 T allele carriers possess the higher TC and LDL levels compared to the non-carriers in all the participants (Both P < 0.05).Conclusions: AGT rs2493132 CT + TT genotype and T allele significantly increased the developing risk of CAD in the patients with NAFLD in Chinese Han population. AGT rs2493132 T allele associated with the increased serum TC and LDL levels.

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Section: Discussionsupporting

confidence: 89%

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Dong

Zhang

et al. 2020

Preprint

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“…MS is a lethal endocrinopathy involving a chain of systemic disorders such as abdominal obesity, glucose intolerance or diabetes mellitus (DM), dyslipidemia, hypertension and CAD. Nowadays many epidemiological and clinical studies are focused on the association between NAFLD and CAD [ 2 , 3 ]. Several studies have reported that NAFLD was a strong independent risk factor for CAD in different racial group and with different research methods [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

Sui

et al. 2016

Lipids Health Dis

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Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.

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“…Some reports demonstrated that because of the promoting effect on CVD, NAFLD patients were at high risk of death [ 8 , 10 ]. Nowadays many epidemiological and clinical studies focus on the association between NAFLD and CAD [ 19 – 24 ]. Several studies have reported that NAFLD is a strong risk factor for CAD [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population

Liu

Lu²,

Yuan

et al. 2016

Lipids Health Dis

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BackgroundCardiovascular disease (CAD) responsible and nonalcoholic fatty liver disease (NAFLD) are both metabolic diseases, and they are mostly influenced by genetic factors. The aim of our study is to evaluate the relationship between angiotensin II type-1 receptor (AGTR1) gene rs3772622 polymorphisms and the risk of developing coronary artery disease (CAD) in Chinese patients with NAFLD.MethodsGenotype for AGTR1 rs3772622 in 574 NAFLD patients with CAD or 589 NAFLD patients without CAD, 332 CAD patients exclude NAFLD and 338 health control subjects were determined by sequencing and polymerase chain reaction analysis. Relevant statistical methods were employed to analyze the genotypes, alleles and the clinical date. Inter-group differences and associations were assessed statistically using t-tests and Chi square and logistic analyses. The relative risk of AGTR1 rs3772622 for NAFLD was estimated by logistic regression analysis.ResultsNo significant difference in genotype and allele frequency of AGTR1 rs3772622 was found between the NAFLD without CAD population and the controls (P > 0.05). However, makeable difference was found when compared the CAD in patients with NAFLD and CAD free NAFLD patients (P < 0.001 OR = 2.09). Similarly, significant difference was found in AGTR1 rs3772622 genotype distribution between the groups of CAD patients and control (P = 0.046 OR = 1.71).ConclusionsAGTR1 rs3772622 gene polymorphism was not associated with the risk of NAFLD, but could increase the risk of NAFLD patients suffering from CAD in the Chinese Han population. Deeply mechanisms underlying the association between AGTR1 rs3772622 gene polymorphism and the risk of CAD in NAFLD patients need more research.

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Nonalcoholic Fatty Liver Disease in Patients With Coronary Disease From a Brazil Northeast Area

Abstract: -Background -Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver injury around the world. It is associated with metabolic syndrome and cardiovascular diseases. Objective -To evaluate the frequency and relevance of NAFLD in patients with coronary artery disease (CAD

Cited by 10 publications

References 22 publications

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population

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