Nonablative Facial Remodeling

Schmults, Chrys D.; Phelps, Robert; Goldberg, David J.

doi:10.1001/archderm.140.11.1373

Cited by 85 publications

(31 citation statements)

References 18 publications

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“…7,21,38,39,42,43,47 Types I and III procollagen mRNA levels peaked at day 21 after CO 2 -laser resurfacing of photodamaged human skin and remained elevated for at least six months. 40 During this dermal remodeling, younger patients seemed to form more new collagen compared with older patients with photodamaged skin 48 and denatured collagen appeared to be metabolized differently according to the depth of damage. Superficially denatured collagen was degraded within two weeks, whereas denatured collagen of Ͼ600 m beneath the skin surface was associated with granulomatous inflammation.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigation of wound healing in response to fractional photothermolysis

et al. 2009

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Despite growing clinical evidence of ablative fractional photothermolysis (AFP), little is known about the spatiotemporal molecular changes within the targeted compartments. Six subjects received three different single AFP treatments using a scanned 250 mum CO(2)-laser beam. Spatiotemporal changes of skin regeneration were estimated by immunohistochemical investigation (HSP70, HSP72, HSP47, TGFbeta, procollagen III, CD3, CD20, and CD68) in skin samples 1 h, 3 days, and 14 days postintervention. The remodeling was uniformly started by regrowth of the epidermal compartment followed by partial to complete replacement of the microscopic ablation zones (MAZ) by newly synthesized condensed procollagen III. From day 3 to 14, the number of macrophages as well as giant cells surrounding the MAZ increased. TGFbeta expression was highest 1 h to 3 days following AFP. HSP70 and HSP72 expressions were highest 3-14 days postintervention in the spinocellular layer leading to an upregulation of HSP47. AFP performed by a scanned CO(2)-laser results in an early epidermal remodeling, which is followed by a dermal remodeling leading to a replacement of the MAZ with newly synthesized (pro)-collagen. During this, an inflammatory infiltrate with CD3(+) and CD20(+) cells surrounds the MAZ. The count of macrophages and giant cells involved in the replacement of the necrotic zones seems to be crucial for wound healing.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigation of wound healing in response to fractional photothermolysis

et al. 2009

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“…Orringer and colleagues hypothesized that such biochemical markers can also be measured in nonablative procedures designed to improve photodamaged skin, providing an objective measure of treatment efficacy. In this context, Schmults and associates 23 recently performed an ultrastructural analysis of photodamaged facial skin treated with the microsecond‐pulsed 1,064‐nm Nd:YAG laser used in our study 23 . Using similar treatment parameters to ours (fluence 13 J/cm 2 , pulse duration 0.3 milliseconds, spot size 5 mm, administered at 7 Hz in a rapid painting motion), they observed a decrease in collagen fiber diameter in the papillary dermis of photodamaged skin ( N =9), demonstrable as early as 1 month after a series of three treatment sessions.…”

Section: Discussionmentioning

confidence: 99%

Nonablative Acne Scar Reduction after a Series of Treatments with a Short-Pulsed 1,064-nm Neodymium:YAG Laser

Lipper

Perez

2006

Dermatol Surg

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Our findings support the use of a short-pulsed, low-fluence 1,064-nm Nd:YAG laser as a safe, effective treatment for facial acne scarring. Scar improvement was noted in all treated subjects with minimal discomfort and no downtime. This protocol appears to be most effective at reducing scar depth and softening scar contours. A laser upgrade needed for the study was provided to the authors at a reduced price.

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“…Collagen fiber diameter was measured by the method described previously with minor modifications (Schmults et al, 2004). Collagen fiber diameter of longitudinally cut fibers was measured directly on the photographs in millimeters by using Image-pro Plus software (Media Cybernetics, Inc., Bethesda, MD, USA), then adjusted for magnification to give a diameter in nanometers.…”

Section: Methodsmentioning

confidence: 99%

Expression and Deposition of Fibrous Extracellular Matrix Proteins in Cardiac Valves during Chick Development

Tan¹,

Junor²,

Price³

et al. 2010

Microsc Microanal

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Extracellular matrix (ECM) plays essential signaling and structural roles required for the proper function of cardiac valves. Cardiac valves initially form as jelly-like cushions, which must adapt to withstand the increased circulation hemodynamics associated with fetal development and birth. This increased biomechanical stability of the developing valves is largely imparted by ECM proteins, which form a highly organized fibrous meshwork. Since heart valve defects contribute to most congenital heart diseases, understanding valve development will provide insight into the pathogenesis of various congenital valve anomalies. Thus, the goal of this study is to describe the spatiotemporal deposition of fibrous ECM proteins during cardiac valve development. Chick embryonic and fetal atrioventricular and semilunar valves were examined by light, confocal, and transmission electron microscopy (TEM). Our data demonstrate that fibrous ECM proteins are deposited when the leaflets are adopting an elongated and compacted phenotype. A general pattern of increased fibrotic ECM deposition was detected in valve tissues. Also, each ECM protein examined displayed a unique pattern of organization, suggesting that regulation of fibrous protein deposition is complex and likely involves both genetic and mechanical factors. In addition, the TEM study revealed the presence of membrane protrusions from valvular endocardium, indicating a potential mechanism for mechanical force transduction.

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Nonablative Facial Remodeling

Cited by 85 publications

References 18 publications

Immunohistochemical investigation of wound healing in response to fractional photothermolysis

Immunohistochemical investigation of wound healing in response to fractional photothermolysis

Nonablative Acne Scar Reduction after a Series of Treatments with a Short-Pulsed 1,064-nm Neodymium:YAG Laser

Expression and Deposition of Fibrous Extracellular Matrix Proteins in Cardiac Valves during Chick Development

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