Non-traumatic Myositis Ossificans as Unusual Cause of Neck Pain During COVID-19 Pandemic: a Case Report

Vitale, Valerio; Bleve, Cosimo; Mansour, Mariam; Corti, Federica De; Giarraputo, Leonardo; Brugiolo, A; Affinita, Maria Carmen; Santoro, Luisa; Chiarenza, Salvatore Fabio; Iannucci, Giuseppe

doi:10.1007/s42399-022-01177-2

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…This reaction also increases the levels of signaling pathways associated with signal transduction, as well as bone-inducing factors such as transforming growth factor-β, leading to the proliferation and differentiation of osteoprogenitor cells and angiogenesis, consequently stimulating MO occurrence[ 13 ]. Several studies have documented a strong correlation between coronavirus disease 2019 (COVID-19) and the development of ectopic ossification[ 14 , 15 ]. Meanwhile, MO cases have occurred among patients receiving the COVID-19 vaccine[ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ilizarov technique for treating elbow stiffness caused by myositis ossificans: A case report

Zhou,

Zhang,

Zhang

et al. 2024

World J Clin Cases

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BACKGROUND Myositis ossificans (MO) is a rare disease involving the formation of bone outside the musculoskeletal system. While surgical intervention is the main treatment approach, preventing recurrence and standardized rehabilitation are also crucial. Here, we present a surgical strategy to prevent the recurrence of MO. CASE SUMMARY A 28-year-old female patient was admitted for the first time for a comminuted fracture of the left olecranon. However, incorrect postoperative rehabilitation resulted in the development of elbow joint stiffness with ectopic ossification, causing a loss of normal range of motion. The patient was diagnosed with MO based on physical examination, X-ray findings, and clinical presentation. We devised a surgical strategy to remove MO, followed by fixation with an Ilizarov frame, and implemented a scientifically reasonable rehabilitation plan. The surgery lasted for 3 h with an estimated blood loss of 45 mL. A drainage tube was placed after surgery, and fluid was aspirated through ultrasound-guided puncture. The patient experienced a significant reduction in joint stiffness after surgery. In the final follow-up at 9 mouths, there was evident improvement in the range of motion of the elbow joint, and no other symptoms were reported. CONCLUSION The Ilizarov frame is an advantageous surgical technique for facilitating rehabilitation after MO removal. It offers benefits such as passive recovery, individualized treatment, and prompt recovery.

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Section: Discussionmentioning

confidence: 99%

Ilizarov technique for treating elbow stiffness caused by myositis ossificans: A case report

Zhou,

Zhang,

Zhang

et al. 2024

World J Clin Cases

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“…In addition to histological features consistent with MO, two authors have assessed the presence of COL1A1-USP6 transcript at PCR analysis (38,43). These were not described previously in the pediatric population.…”

Section: Biopsy and Histological Featuresmentioning

confidence: 99%

Myositis ossificans in the pediatric population: a systematic scoping review

Cherry,

Mutschler,

Samara

et al. 2023

Front. Pediatr.

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IntroductionCircumscribed or pseudomalignant myositis ossificans (MO) is a rare and benign condition characterized by heterotopic bone formation in soft tissues. The clinical presentation of MO, imaging investigations, histological findings, and treatment strategies are unclear, especially in the pediatric population.Materials and methodsA literature search was conducted in PubMed, Scopus, and Google Scholar electronic databases to identify original articles and reviews in English or French of traumatic and non-traumatic MO. Studies were selected by 2 independent reviewers following the PRISMA recommendation and descriptive data were extracted. We harvest in each case the sex, age at diagnosis, location, presence of initial trauma, pre-emptive diagnosis, modalities of imagery used, realized biopsy, treatment performed, and type of follow-up.ResultsSixty pediatric cases of MO were identified between 2002 and 2023. Twenty-three patients (38.3%) were diagnosed with idiopathic/pseudomalignant and 37 patients (61.7%) with circumscribed. The mean age at diagnosis was 9.5 years (range 0.2–17 years), with a male-to-female ratio of 1:1. The initial pre-emptive diagnosis was neoplasia in 13 patients (21.7%). The biopsy was percutaneous in 9 patients (15%) and incisional in 7 patients (11.7%). Histological analysis was achieved in 35 cases (57%). Surgical excision was the first line treatment in 46.7% of patients, and non-surgical in the remaining patients. The follow-up strategy was clinical in 16 patients (26.7%) or based on imaging investigation in 23 patients (38.3%).DiscussionAlthough MO in children is described as a rare pathology, identifying the benignity of the condition is essential to avoid unnecessary invasive treatment and to avoid delaying the treatment of a potentially life-threatening entity. It seems that there is no consensus established concerning the proper imaging for diagnosis. Clinicians should acknowledge that the absence of a triggering trauma tends to direct the investigation and the management toward a surgical attitude. Conservative management is key, however, surgical excision can be proposed on matured lesions on a case-by-case basis. The absence of recurrence is not excluded. Therefore, a close clinical follow-up is suggested for all cases. The true benefit of a radiological is questioned in a question known to be self-resolving.

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Non-traumatic Myositis Ossificans as Unusual Cause of Neck Pain During COVID-19 Pandemic: a Case Report

Cited by 2 publications

References 6 publications

Ilizarov technique for treating elbow stiffness caused by myositis ossificans: A case report

Ilizarov technique for treating elbow stiffness caused by myositis ossificans: A case report

Myositis ossificans in the pediatric population: a systematic scoping review

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