Non-organ specific autoantibodies in children with chronic hepatitis C

Bortolotti, Flavia; Vajro, Pietro; Balli, Fiorella; Giacchino, Raffaella; Crivellaro, Carlo; Barbera, Cristiana; Cataleta, Michela; Muratori, Luigi; Pontisso, Patrizia; Nebbia, Gabriella; Zancan, Lucia; Bertolini, A.; Alberti, Alfredo; Bianchi, Francesco

doi:10.1016/s0168-8278(96)80228-5

Cited by 83 publications

(73 citation statements)

References 24 publications

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“…The presence of autoantibodies in 80% of our HCV þ patients on at least one occasion is higher than that reported by Abuaf et al [4] (46%), Bortolotti et al [9] (35%) and McFarlane et al [6] (19%). One possible explanation for the difference is that we have determined the presence of autoantibodies on serial samples taken at least 1 month apart, while most published data have only done a single point determination.…”

Section: Discussioncontrasting

confidence: 63%

“…In view of the fluctuating behaviour of autoantibodies, a single point determination may not provide complete information on autoantibody prevalence in these patients. Additional reasons for the difference in autoantibody prevalence between ours and the cited studies [4][5][6][7][8][9] may derive from technical differences and differences in the populations investigated. Akin to our study, Abuaf et al [4] and McFarlane et al [6] have used the conventional screening dilution of 1/10 to examine the presence of autoantibodies, as originally proposed by Holborow & Johnson [19]; however, these studies [4][5][6][7][8] are not immediately comparable to ours, as they were conducted in adult populations.…”

Section: Discussionmentioning

confidence: 84%

“…Akin to our study, Abuaf et al [4] and McFarlane et al [6] have used the conventional screening dilution of 1/10 to examine the presence of autoantibodies, as originally proposed by Holborow & Johnson [19]; however, these studies [4][5][6][7][8] are not immediately comparable to ours, as they were conducted in adult populations. In the only study in children with chronic HCV infection examining the prevalence of autoimmune serology, Bortolotti et al [9] reported a positivity for SMA in 18%, LKM-1 in 10% and ANA in 7% using a screening dilution of 1/20. Our results would have been similar to Bortolotti's [9] had we used a screening dilution of 1/20.…”

Section: Discussionmentioning

confidence: 99%

“…In the only study in children with chronic HCV infection examining the prevalence of autoimmune serology, Bortolotti et al [9] reported a positivity for SMA in 18%, LKM-1 in 10% and ANA in 7% using a screening dilution of 1/20. Our results would have been similar to Bortolotti's [9] had we used a screening dilution of 1/20. However, particularly in the paediatric age group, a starting dilution of 1/10 should be used, as autoantibodies at any titre are rare in healthy children.…”

Section: Discussionmentioning

confidence: 99%

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Autoantibody prevalence in children with liver disease due to chronic hepatitis C virus (HCV) infection

Gregorio

Pensati

Iorio

et al. 1998

Clinical and Experimental Immunology

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SUMMARYHCV infection and interferon-alpha (IFN-a) therapy have been associated with autoimmunity. To assess whether chronic liver disease (CLD) due to HCV infection or its treatment with IFN-a cause autoimmune manifestations, the prevalence of tissue autoantibodies in 51 children with chronic HCV infection and 84 with other CLD was analysed by standard techniques. Sixty-five percent of patients with chronic HCV infection, 66% with chronic hepatitis B infection and 60% with Wilson's disease were positive for at least one autoantibody. In the 51 subjects with chronic HCV infection (29 treated with IFN-a, 22 untreated), tested on 165 occasions over a median of 9 months (range 5-42 months), autoantibodies to nuclei (ANA), smooth muscle (SMA), gastric parietal cell (GPC) and/or liver kidney microsomal type 1 (LKM-1) were similarly prevalent in treated and untreated patients (90% versus 68%, P ¼ 0·12). Positivity for SMA was present in 67%, GPC in 32%, ANA in 10%, LKM-1 in 8% of cases. Treatment with IFN-a had to be suspended due to transaminase elevation in one SMA-positive, one ANA-positive but in three of four LKM-1-positive patients. Our results show that: (i) autoantibodies are common in viral-induced hepatitis and Wilson's disease; (ii) positivity for SMA, GPC, ANA is part of the natural course of chronic HCV infection, their prevalence being unaffected by IFN-a; and (iii) IFN-a should be used cautiously in the treatment of LKM-1/HCV-positive patients.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Autoantibody prevalence in children with liver disease due to chronic hepatitis C virus (HCV) infection

Gregorio

Pensati

Iorio

et al. 1998

Clinical and Experimental Immunology

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“…Thyroid dysfunction and thyroid autoimmune disease is rare, but thyroid‐specific antibodies, subclinical hypothyroidism, and autoimmune thyroiditis have been described in children 53, 54, 55. Development of nonorgan‐specific autoantibodies, such as antinuclear antibodies, is well recognized,53, 54, 56, 57, 58 although their clinical significance is debated 54, 59. Finally, some manifestations, such as the cutaneous features of vasculitis and porphyria cutanea tarda described in adults, have not been reported in children 42, 60…”

Section: Clinical Featuresmentioning

confidence: 99%