Non-Melanoma Skin Cancer Incidence and Impact of Skin Cancer Screening on Incidence

Abstract

Non-melanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized. This analysis has two objectives: first, to provide up-to-date incidence estimates by sex, age group, histological type, and body site; and second, to study the impact of skin cancer screening. The impact of screening on NMSC incidence in Schleswig-Holstein, Germany, is analyzed by comparing four time periods of different screening settings (no screening (1998-2000), pilot project (Skin Cancer Research to Provide Evidence for Effectiveness of Screening in Northern Germany, SCREEN, 2003-2004), after SCREEN (2004-2008), and nation-wide skin cancer screening (2008-2010)) to a reference region (Saarland, Germany). Age-standardized (Europe) NMSC incidence was 119/100,000 for women and 145/100,000 for men in the most recent screening period in Schleswig-Holstein (2008-2010). During implementation of SCREEN (2003-2004), incidence increased from 81.5/100,000 to 111.5/100,000 (1998-2000) by 47% for women and 34% for men. All age groups in women were affected by the increase, but increases for men were mostly limited to the older age groups. Incidence in Saarland first increased slowly, but increased steeply with the introduction of the nation-wide skin cancer screening in 2008 (+47% for women and +40% for men, reference 2004-2008). Observed changes are most likely attributed to screening activities.

Evaluation of the Cases Who Were Referred to Plastic Surgery Clinic Out of Suspicion of Non-melanoma Skin Cancer Localized at Head and Neck Region in Sivas Numune Hospital

“…Turkiye Klinikleri J Dermatol 2016;26 (2) Skuamöz hücreli karsinomlarda hücre diferansiasyonu önemli bir prognostik faktördür. Kötü diferansiye tümörler metastaz ve nüks açısından yüksek riskli kabul edilir.…”

“…NMCK'ların %85'ini bazal hücreli karsinomlar oluştururken, %15'ini skuamöz hücreli karsinomlar oluşturur. 2 Diğer nadir görülen NMCK'lar toplamda %1'den az görülmektedir. 3 Melanositik ve NMCK'lar için ortak risk faktörleri güneş maruziyeti ve DNA onarım defektleridir.…”

Clinical Findings, Treatments and Outcomes of Transplant Recipients with Metastatic Skin Cancer

“…Skin cancers account for 40% of malignancies seen in SOTRs and the majority are squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) [1][2][3][4] . Unlike the non-immunosuppressed population, SOTRs are more likely to develop SCC than BCC.…”

HPV vaccination for prevention of skin cancer

“…NMSC, which comprises basal cell carcinoma (BCC, approximately 80% of cases), squamous cell carcinomas (SCC, approximately 20% of cases) and other less frequent entities, is the most frequent malignancy in the Caucasian population. 7 The main risk factor for NMSC is exposure to UV radiation, since more than 80% of the lesions appear in sunexposed areas. Another important risk factor is immunosuppression, with SCC Keywords: cutaneous papillomaviruses, non melanoma skin cancer, vaccination Abbreviations: BCC, basal cell carcinoma; EV, Epidermodysplasia Verruciformis; HPV, Human Papillomavirus; NMSC, non melanoma skin cancer; SCC, squamous cell carcinoma; VLP, virus-like particle.…”

“…14,35 Although mortality from NMSC is rare in the immunocompetent population, this malignancy represents a considerable burden on the health-care system, particularly when considering immunosuppressed patients. 7 It is estimated that up to 40% of OTR will develop skin cancers, 90% of which are BCC and SCC, within the first 10 y of transplantation, and up to 80% will do so after 20 y 36 Additionally, skin malignancies are more aggressive in OTRs, with only 56% of 3-year diseasespecific survival. 37 Therefore, a prophylactic strategy that could prevent or reduce the impact of these skin manifestations is much needed.…”