Non-invasive determination of tumor oxygen tension and local variation with growth

Mason, Ralph P.; Antich, Peter P.; Babcock, Evelyn E.; Constantinescu, A; Peschke, Peter; Hahn, Eric

doi:10.1016/0360-3016(94)90231-3

Cited by 100 publications

(86 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This led to substantial hepatomegaly and splenomegaly and was unsatisfactory for general application (148,149). Moreover, PFC signal was often detected from the tumor periphery, corresponding to only the most well-perfused regions (150). These regions are typically the best oxygenated and thus the least important in terms of tumor response to oxygen-dependent therapy.…”

Section: Reporter Molecules For Mr Oximetrymentioning

confidence: 99%

Molecular Imaging of Hypoxia

2008

Self Cite

View full text Add to dashboard Cite

Section: Reporter Molecules For Mr Oximetrymentioning

confidence: 99%

Molecular Imaging of Hypoxia

2008

Self Cite

View full text Add to dashboard Cite

“…This is ideal for investigating pO 2 in the liver or spleen, but a major shortcoming for other tissues, since animals may exhibit extensive hepatomegaly or splenomegaly though there is no apparent toxicity [227,238,240]. Long-term retention in tissues allows pO 2 measurements to be made in vivo and extensive studies have been reported in liver, spleen, abscess, perfused heart, and tumors [5,9,62,218,[241][242][243][244][245][246][247][248][249][250][251][252][253][254].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…regions [242,254]. Indeed, pO 2 values measured soon after intravenous infusion, but following vascular clearance (typically 2 days), are generally high, approaching arterial pO 2 [242].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…Indeed, pO 2 values measured soon after intravenous infusion, but following vascular clearance (typically 2 days), are generally high, approaching arterial pO 2 [242]. Thus, physiological measurements with respect to intervention are biased towards the well-perfused, well-oxygenated regions, which are often less important than hypoxic regions.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…Such long-term tissue marking has been proposed as a form of noninvasive histology [255]. Long tissue retention has the advantage of facilitating chronic studies during tumor development and progressive tumor hypoxiation has been observed over many days [242,245].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

See 2 more Smart Citations

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

Self Cite

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

show abstract

Synergistic interaction of ultrasonic shock waves and hyperthermia in the dunning prostate tumor r3327-at1

et al. 1999

Self Cite

View full text Add to dashboard Cite

Pulsed high‐energy ultrasound shock waves (PHEUS), similar to those used for clinical lithotripsy, can deposit energy deep in tissue and thereby destroy the microvasculature of solid tumors. We investigated the potential of PHEUS, generated by an electromagnetic shockwave source (19 kV capacitor voltage, 1 Hz pulse frequency), as a local cancer‐therapy modality alone and in combination with local tumor hyperthermia (43.5 ± 0.1°C, 30 min). Copenhagen rats transplanted with the anaplastic Dunning‐prostate‐tumor sub‐line R3327‐AT1 received 1000 PHEUS pulses, which delayed tumor growth by one tumor‐doubling time (5 days). Histopathology revealed hemorrhage, disruption of tumor vasculature, and necrosis in the focus of the sound field. Bromodeoxyuridine (BUdR) incorporation was significantly lower in PHEUS‐treated tumors than in controls. Dynamic magnetic resonance imaging (MRI) studies using gadolinium‐DTPA as contrast agent showed a strong reduction of tumor perfusion after PHEUS treatment, although this effect was partly reversible within 3 days after PHEUS. While hyperthermia alone produced no significant delay in tumor growth, the combination of PHEUS and hyperthermia produced tumor‐growth delay by 2 tumor‐volume‐doubling times. The maximum growth delay was achieved when PHEUS and hyperthermia were separated by 24 hr at the time of maximum perfusion reduction indicated by MRI. Thus, the cytotoxic effect of PHEUS was enhanced by hyperthermia in the anaplastic prostate tumor R3327‐AT1 grown on Copenhagen rats in a synergistic manner, due to blood‐flow reduction. In conjunction with other agents, such as hyperthermia, PHEUS might become a local cancer‐therapy modality in solid tumors accessible to ultrasound. Int. J. Cancer 82:84–91, 1999. © 1999 Wiley‐Liss, Inc.

show abstract

Non-invasive determination of tumor oxygen tension and local variation with growth

Cited by 100 publications

References 38 publications

Molecular Imaging of Hypoxia

Molecular Imaging of Hypoxia

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Synergistic interaction of ultrasonic shock waves and hyperthermia in the dunning prostate tumor r3327-at1

Contact Info

Product

Resources

About