Non-invasive brain stimulation of the aging brain: State of the art and future perspectives

Tatti, Elisa; Rossi, Símone; Innocenti, Iglis; Rossi, Alessandro; Santarnecchi, Emiliano

doi:10.1016/j.arr.2016.05.006

Cited by 70 publications

(64 citation statements)

References 247 publications

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“…What is emerging as a possible role for non-invasive neuromodulation is the coupling of stimulation with cognitive therapy, with the aim to promote plastic associative learning mechanisms to synergically improve the effects of cognitive rehabilitation only [427–429]. This approach, while still in need of quantitative characterization [430–432] seems promising only in mild AD, when the severity of neurodegeneration makes still available a residual neural substrate to possibly intervene on [433]. …”

Section: Contribution and Role Of Neuromodulationmentioning

confidence: 99%

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Hampel

Toschi

Babiloni

et al. 2018

JAD

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126

113

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The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer’s disease (AD). The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group “Alzheimer Precision Medicine” (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development towards breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND.

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Section: Contribution and Role Of Neuromodulationmentioning

confidence: 99%

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Hampel

Toschi

Babiloni

et al. 2018

JAD

Self Cite

126

113

View full text Add to dashboard Cite

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“…These mentioned interventions, which are schematically summarized in Figure 2, are mainly based on CIs, PE (for a review of both types of intervention, see Bamidis et al, 2014), and NIBS (for a review, see Tatti et al, 2016). (Clare and Woods, 2004).…”

Section: Non-pharmacological Interventions To Improve Cognition In Hementioning

confidence: 99%

“…However, no NIBS studies have combined both functional and structural cortical modulations (for a recent review, see Tatti et al 2016). Indeed, only two NIBS studies used multiple sessions to investigate neural changes during advanced stages of life (Devi et al, 2014;Kehdr et al, 2014).…”

Section: Relationships Among Cognitive Improvement Neural Changes Anmentioning

confidence: 99%

Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity

Cespón

Miniussi

Pellicciari

2018

Ageing Research Reviews

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A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive training, physical exercise and non-invasive brain stimulation in healthy elderly and cognitively impaired subjects (including patients with mild cognitive impairment (MCI) and Alzheimer's disease). Moreover, given the clinical relevance of neuroplasticity, we discuss how evidence for neuroplasticity can be inferred from the functional and structural brain changes observed after implementing these interventions. We emphasize that multimodal programmes, which combine several types of interventions, improve cognitive function to a greater extent than programmes that use a single interventional approach. We suggest specific methods for weighting the relative importance of cognitive training, physical exercise and non-invasive brain stimulation according to the functional and structural state of the brain of the targeted subject to maximize the cognitive improvements induced by multimodal programmes.

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“…Given the neurodegenerative nature of AD, one of the most prominent underlying pathological changes affecting the brain consists in the progressive loss of neurons and the consequent decrease in the amount of grey matter and associated degree of neural plasticity, which starts in the entorhinal cortex and hippocampal areas and progressively involves the entire brain [136]. A better understanding of the underlying changes in neuroplasticity have been investigated through the implementation of transcranial magnetic stimulation (TMS) [137], leading to the development of ad-hoc interventional approaches targeting spared plasticity mechanisms and consequently potentiate cognition [138,139]. As stated in Faraday's Law of electromagnetic induction, TMS can be operated to modulate cortical excitability by means of a magnetic pulse delivered by the coil to an underlying population of neurons, directly causing a discharge of action potentials [140,141].…”

Section: Nibs and Its Potential Contribution To Cr Theorymentioning

confidence: 99%

The Role of Cognitive Reserve in Alzheimer’s Disease and Aging: A Multi-Modal Imaging Review

Menardi

Pascual‐Leone

Fried

et al. 2018

JAD

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Comforts in modern society have generally been associated with longer survival rates, enabling individuals to reach advanced age as never before in history. With the increase in longevity, however, the incidence of neurodegenerative diseases, especially Alzheimer's disease, has also doubled. Nevertheless, most of the observed variance, in terms of time of clinical diagnosis and progression, often remains striking. Only recently, differences in the social, educational and occupational background of the individual, as proxies of cognitive reserve (CR), have been hypothesized to play a role in accounting for such discrepancies. CR is a well-established concept in literature; lots of studies have been conducted in trying to better understand its underlying neural substrates and associated biomarkers, resulting in an incredible amount of data being produced. Here, we aimed to summarize recent relevant published work addressing the issue, gathering evidence for the existence of a common path across research efforts that might ease future investigations by providing a general perspective on the actual state of the arts. An innovative model is hereby proposed, addressing the role of CR across structural and functional evidences, as well as the potential implementation of non-invasive brain stimulation techniques in the causal validation of such theoretical frame.

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Non-invasive brain stimulation of the aging brain: State of the art and future perspectives

Cited by 70 publications

References 247 publications

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity

The Role of Cognitive Reserve in Alzheimer’s Disease and Aging: A Multi-Modal Imaging Review

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