Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

Zubeldia‐Varela, Elisa; Barker-Tejeda, Tomás Clive; Blanco-Pérez, Frank; Infante, Sonsoles; Zubeldia, José Manuel; Pérez‐Gordo, Marina

doi:10.3390/foods10112662

Cited by 13 publications

(10 citation statements)

References 102 publications

(137 reference statements)

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“…Entamoeba histolytica and the implications were studied 138 . Taking the greater longevity into perspective, studies on reptile GM should give an in depth account to the epigenetic changes 139 . Combining epigenetic changes and GM could unearth the mechanisms underpinning non‐IgE‐mediated gastrointestinal food allergy 140 .…”

Section: Discussionmentioning

confidence: 99%

“…138 Taking the greater longevity into perspective, studies on reptile GM should give an in depth account to the epigenetic changes. 139 Combining epigenetic changes and GM could unearth the mechanisms underpinning non-IgEmediated gastrointestinal food allergy. 140 Although epigenetic factors are studied to mediate the interaction between the genome and environment, both intestinal immune homeostasis monogenic defects and very early-onset IBD are hopeful for new direction of treatment.…”

Section: Systematic Review O Scfas Concentrations In Crc Patients And...mentioning

confidence: 99%

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The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

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Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system‐related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics modifications and GM as biomarkers that could confer effective diagnostics and confer treatment options. To this end, this review hopes to give detailed information on connecting the modifications in epigenetic and GM. An updated and detailed information on the connection between the epigenetics factors and GM that influence diseases are given. In addition, the review showed some associations between the epigenetics to the maternal GM and offspring health. Finally, the limitations of the concept and prospects into this new emerging discipline were also looked into. Although this review elucidated on the maternal diet and response to offspring health with respect to GM and epigenetic modifications, there still exist various limitations to this newly emerging discipline. In addition to integrating complementary multi‐omics data, longitudinal sampling will aid with the identification of functional mechanisms that may serve as therapeutic targets. To this end, this review gave a detailed perspective into harnessing disease diagnostics, prevention and treatment options through epigenetics and GM.

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Section: Discussionmentioning

confidence: 99%

Section: Systematic Review O Scfas Concentrations In Crc Patients And...mentioning

confidence: 99%

The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…AAFs are recommended when symptoms do not resolve with EHF, failure to thrive, multiple food allergies, and eosinophilic esophagitis. 73,74 The European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) and the American Academy of Pediatrics (AAP) recommended avoiding soybased formulas due to a high risk of co-reactivity with cow's milk. In addition, there are concerns based on animal data regarding the phytoestrogen content in soy-based formula and the potential risk for infants, especially premature and infants with congenital hypothyroidism (CH).…”

Section: Dovepressmentioning

confidence: 99%

Perspectives on Non-IgE-Mediated Gastrointestinal Food Allergy in Pediatrics: A Review of Current Evidence and Guidelines

Al-Iede¹,

Sarhan²,

Alshrouf³

et al. 2023

JAA

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Food allergy is an immune-mediated disease that can result in considerable morbidity and even mortality, with a significant negative impact on patients' quality of life. It is characterized by allergic symptoms that can occur shortly after a relevant food allergen ingestion, or can be delayed or chronic, which make it more difficult for diagnosis. The symptoms of this disease can range from mild to severe, and rarely can cause anaphylaxis, a life-threatening allergic reaction. The prevalence of non-immunoglobulin E (IgE)mediated food allergy is poorly established outside of cow's milk allergy, with an adjusted incidence ranging between 0.13% and 0.72%. Several disorders are classified as non-immunoglobulin E (IgE)-mediated food allergies that predominantly affect the gastrointestinal tract including food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), food protein-induced allergic enteropathy (FPE), and food protein-induced dysmotility disorders (GORD and constipation). Eosinophilic esophagitis (EoE) is listed in this group, even though it considered by some authorities to be mixed reaction with both IgE and cell-mediated immune response to be involved in the reaction. The most common types of non-IgE-mediated food allergy are food protein-induced enterocolitis syndrome (FPIES) and food protein-induced allergic proctocolitis (FPIAP). These disorders typically present in infancy and are often triggered by cow's milk protein. Patients with FPIES present with profuse emesis and dehydration, while FPIAP patients present with hematochezia in otherwise healthy infants. Since there are no specific confirmatory non-invasive diagnostic laboratory tests, the diagnosis is usually made clinically when typical symptoms improve upon the removal of the culprit food. Food reintroduction should be attempted, when possible, with documentation of symptoms of relapse to confirm the diagnosis. The management includes dietary avoidance, supportive treatment in the case of accidental exposure, and nutritional counseling. This review focuses on the clinical manifestations, epidemiology, management, and recent guidelines of the most common non-IgEmediated food hypersensitivity disorders (FPIES, FPIAP, and FPE).

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“…IgE-mediated food allergy is much more common than non-IgE-mediated food allergy, symptoms are easily recognizable, and underlying mechanisms are better established. Although the relationship between food allergy and gastrointestinal dysfunction has been known for several years, the exact mechanisms involved have yet to be clearly defined [120].…”

Section: Microbiome and Food Allergymentioning

confidence: 99%

Microbiome and Allergy: New Insights and Perspectives

Zubeldia-Varela¹,

Barker-Tejeda²,

Obeso³

et al. 2022

J Investig Allergol Clin Immunol

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The role of the microbiome in the molecular mechanisms underlying allergy has become highly relevant in recent years. Studies are increasingly suggesting that altered composition of the microbiota, or dysbiosis, may result in local and systemic alteration of the immune response to specific allergens. In this regard, a link has been established between lung microbiota and respiratory allergy, between skin microbiota and atopic dermatitis, and between gut microbiota and food allergy. The composition of the human microbiota is dynamic and depends on host-associated factors such as diet, diseases, and lifestyle. Omics are the techniques of choice for the analysis and understanding of the microbiota. Microbiota analysis techniques have advanced considerably in recent decades, and the need for multiple approaches to explore and comprehend multifactorial diseases, including allergy, has increased. Thus, more and more studies are proposing mechanisms for intervention in the microbiota. In this review, we present the latest advances with respect to the human microbiota in the literature, focusing on the intestinal, cutaneous, and respiratory microbiota. We discuss the relationship between the microbiome and the immune system, with emphasis on allergic diseases. Finally, we discuss the main technologies for the study of the microbiome and interventions targeting the microbiota for prevention of allergy.

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Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

Cited by 13 publications

References 102 publications

The connection between epigenetics and gut microbiota‐current perspective

The connection between epigenetics and gut microbiota‐current perspective

Perspectives on Non-IgE-Mediated Gastrointestinal Food Allergy in Pediatrics: A Review of Current Evidence and Guidelines

Microbiome and Allergy: New Insights and Perspectives

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