Non-Healing Granulomata of the Nose

The Oral and Pharyngeal Manifestations of Skin Disease

“…There is, however, considerable support for Friedmann's (1955) opinion that there are two groups: one, the classical type with external ulceration of the face, no giant cells in the necrotic tissue and no evidence of polyarteritis at autopsy; the other with little outward evidence of destruction, giant cell histology, ulcers of the palate, larynx and trachea with widespread necrotizing angiitis and granulomatous lesions in the lung, kidney and other organs. Walton (1959), whilst agreeing with the division into these two groups, has also added a third, small group of patients who have a true reticulum cell sarcoma which metastasizes.…”

Idiopathic midline destructive disease—case report and review of the literature

“…Both sexes may be affected, and the mean age of onset is 35 years. Although the cause is unknown, it has been proposed the disorder results from a fulminant inflammatory response to an unknown antigen (Walton, 1959). The development of hypersensitivity type skin reactions in two cases and disseminated inflammatory and vasculitic disease in a third is in keeping with this hypothesis (Fauci et al, 1976;Tsokos et al, 1982).…”

McBride and the midfacial granuloma syndrome

“…The ever growing number of publications make it dif cult to compile a complete list. A plethora of terms has been introduced, including 'malignant granuloma' (Woods, 1921), 'granuloma gangraenescens' (Kraus, 1929); 'progressive lethal granulomatous ulceration' (Stewart, 1933); 'lethal midline granuloma' (Williams, 1949); 'non-healing midline granuloma' (Walton, 1959); 'polymorphic reticulosis' (Eichel, Harrison, Devine, Scanlon and Brown, 1966); 'midline malignant reticulosis' (Kassel, Echevarria and Guzzo, 1969); 'idiopathic midline granuloma' (Fauci, Johnson and Wolff, 1976); 'idiopathic midline destructive disease' (Tsokos, Fauci and Costa, 1980); 'respiratory vasculitis' (DeRemee, Weiland and McDonald, 1980). Woods' term 'malignant granuloma' has been losing favour and, although Williams' expression 'lethal midline granuloma' has the merit of directing attention to the topographical region of the presenting lesion, it has been criticized for implying a hopeless prognosis which is now inappropriate, as in the term 'non-healing'.…”