Non-fatal Bronchiolitis Obliterans Possibly Associated with Tiopronin. A Case Report with Long Term Follow-up

Demaziere, A.; Maugars, Yves; Chollet, S.; Prost, A.

doi:10.1093/rheumatology/32.2.172-a

Cited by 11 publications

(4 citation statements)

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“…Fatal bronchiolitis was also reported 6 months after initiating chrysotherapy in a patient with juvenile rheumatoid arthritis [188]. Tiopronin, another drug sometimes utilised in the treatment of rheumatoid arthritis, has been associated with bronchiolitis in a very limited number of cases [55,189].…”

Section: Drug-induced Small Airways Diseasementioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

European Respiratory Review

104

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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

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Section: Drug-induced Small Airways Diseasementioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

European Respiratory Review

104

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“…cyclophosphamide administration proved effective only in selected cases [67], but results become nearly negligible when larger patient series are considered. of associated "pure" BOOP during gold salts, penicillamin, and tiopronin administration [72,73], had a particular impact. When surgical lung biopsy and histopathology were available, a concentric constrictive bronchiolitis has been identified ( Table 4).…”

Section: Bronchiolitis Obliterans and Organi-zing Pneumonia (Boop) Inmentioning

confidence: 99%

Bronchiolitis Obliterans-Organizing Pneumonia and Related Conditions in Adult Patients

Dentale¹,

Poletti²,

Manfredi³

et al. 2005

CRMR

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Bronchiolitis obliterans and organizing pneumonia (BOOP) represent complex clinical syndromes expressing a similar morphologic pattern, which are observed in a variety of lung diseases. In this view, the Authors report on the clinical and diagnostic profile, radiological features, laboratory and histopathological findings, and management issues of these broad-spectrum pulmonary disorders. Idiopathic forms, infectious disease-associated features, complications of solid organ transplant recipients and bone marrow recipients, collagen vascular-and bowel inflammatory-related forms, the role of drugs and that of irritating and toxic inhalants, and more infrequent ethiologies (which are able to support a bronchiolitis obliterans-organizing pneumonia and related conditions), all these items are thoroughly discussed on the ground of our own experience in this field, and an updated literature review.

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“…A potential relationship with drug intake should be deeply investigated and taken into account in combination with the underlying disease. [26][27][28] The presence on auscultation of wheezing, inspiratory squeaks, or crackles, and pulmonary function tests indicating an air flow obstruction should point to the bronchioles as the likely anatomic site involved. An increase of Ca 19-9 has been reported in diffuse panbronchiolitis, 29 in idiopathic bronchiolitis, 30 and in patients with obstructive bronchiolitis related to graft versus host disease (personal experience).…”

Section: Diagnosismentioning

confidence: 99%

Bronchiolar Disorders: Classification and Diagnostic Approach

Poletti¹,

Costabel²

2003

Seminars in Respiratory and Critical Care Medicine

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Bronchiolitis is a process in which inflammatory cells and mesenchymal tissue are both present, mainly centered in and around membranous and/or respiratory bronchioles, with sparing of a considerable portion of the other parenchymal structures. The distribution and amounts of the cellular and mesenchymal components vary from case to case, which accounts for the variety of histopathologic, radiographic, and clinical aspects of bronchiolitis. The clinical classification of bronchiolar diseases considers the causes or the clinical settings in which bronchiolitis develops: inhalation of toxic fumes, irritant gases or organic dusts, infectious and postinfectious bronchiolitis, collagen-vascular disease-associated bronchiolitis, posttransplant bronchiolitis, or rarer associations. A morphological classification based on histologic characteristics takes into account four main histologic patterns: cellular bronchiolitis, bronchiolitis with inflammatory/intraluminal polyps, constrictive or cicatritial bronchiolitis, peribronchiolar fibrosis, and bronchiolar metaplasia. High-resolution computed tomographic scanning (HRCT) is currently the best imaging technique for the evaluation of patients suspected of having bronchiolitis. HRCT findings in bronchiolar diseases with a good correlation with histopathologic changes are classified as follows: centrilobular tubular branching or nodular opacities; ground-glass attenuation or consolidation; mosaic perfusion; a mixed pattern. This article presents and briefly discusses the diagnostic approach to these diseases.

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Non-fatal Bronchiolitis Obliterans Possibly Associated with Tiopronin. A Case Report with Long Term Follow-up

Cited by 11 publications

References 0 publications

Small airways diseases, excluding asthma and COPD: an overview

Small airways diseases, excluding asthma and COPD: an overview

Bronchiolitis Obliterans-Organizing Pneumonia and Related Conditions in Adult Patients

Bronchiolar Disorders: Classification and Diagnostic Approach

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