Non-familial olivopontocerebellar atrophy combined with late onset Alzheimer's disease: a clinico-pathological case report

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

“…The histopathological hallmark is the formation of α-synuclein-positive and Gallyas-positive argyrophilic glial cytoplasmic inclusions 2 9 10 11 12. The inclusions may be also stained with ubiquitin,9 as found in this case.…”

“…In support of the central mechanism, a histochemical study has confirmed severe loss of putative chemosensitive neurons, accumulation of α-synuclein immunoreactive glial inclusions as well as marked fibre gliosis in the medulla in cases of MSA 10 11 12. Additionally, given that autonomic failure is a prominent feature of MSA, a pathological involvement of autonomic neurons would contribute to respiratory arrest in MSA 3 4.…”

“…However, the immunoreactivity was preserved for α-synuclein and ubiquitin, consistent with MSA. Aggregation of α-synuclein underlies α-synucleinopathies including MSA, Parkinson disease, dementia with Lewy bodies (LBs), diffuse LB disease and the LB variant of Alzheimer disease 9 10 11 12 13…”

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

“…The histopathological hallmark is the formation of α-synuclein-positive and Gallyas-positive argyrophilic glial cytoplasmic inclusions 2 9 10 11 12. The inclusions may be also stained with ubiquitin,9 as found in this case.…”

“…In support of the central mechanism, a histochemical study has confirmed severe loss of putative chemosensitive neurons, accumulation of α-synuclein immunoreactive glial inclusions as well as marked fibre gliosis in the medulla in cases of MSA 10 11 12. Additionally, given that autonomic failure is a prominent feature of MSA, a pathological involvement of autonomic neurons would contribute to respiratory arrest in MSA 3 4.…”

“…However, the immunoreactivity was preserved for α-synuclein and ubiquitin, consistent with MSA. Aggregation of α-synuclein underlies α-synucleinopathies including MSA, Parkinson disease, dementia with Lewy bodies (LBs), diffuse LB disease and the LB variant of Alzheimer disease 9 10 11 12 13…”

Elevation of Zinc Transporter ZnT3 Protein in the Cerebellar Cortex of the AβPP/PS1 Transgenic Mouse

“…We also found that both ZnT3 immunofluorescence and AMG zinc are present in the amyloid plaques of the cerebellar cortex in AβPP/PS1 transgenic mice. Since the cerebellum is a brain region that is known to be affected both functionally and pathologically by AD [7][8][9]27], overexpression of ZnT3 and a resulting zinc distribution may play a role in the formation of senile plaques in the cerebellum.…”

“…Significant changes in biological functions associated with the cerebellum are often observed in advanced stages of AD [7][8][9]. Several studies have demonstrated a reduced nucleolar volume [10] and regression of dendritic trees of Purkinje cells [11], increased microglia [12], and the presence of Aβ deposits [13][14][15] in the AD cerebellum.…”

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

“…The histopathological hallmark is the formation of α-synuclein-positive and Gallyas-positive argyrophilic glial cytoplasmic inclusions 2 9 10 11 12. The inclusions may be also stained with ubiquitin,9 as found in this case.…”

“…In support of the central mechanism, a histochemical study has confirmed severe loss of putative chemosensitive neurons, accumulation of α-synuclein immunoreactive glial inclusions as well as marked fibre gliosis in the medulla in cases of MSA 10 11 12. Additionally, given that autonomic failure is a prominent feature of MSA, a pathological involvement of autonomic neurons would contribute to respiratory arrest in MSA 3 4.…”

“…However, the immunoreactivity was preserved for α-synuclein and ubiquitin, consistent with MSA. Aggregation of α-synuclein underlies α-synucleinopathies including MSA, Parkinson disease, dementia with Lewy bodies (LBs), diffuse LB disease and the LB variant of Alzheimer disease 9 10 11 12 13…”

Elevation of Zinc Transporter ZnT3 Protein in the Cerebellar Cortex of the AβPP/PS1 Transgenic Mouse

“…We also found that both ZnT3 immunofluorescence and AMG zinc are present in the amyloid plaques of the cerebellar cortex in AβPP/PS1 transgenic mice. Since the cerebellum is a brain region that is known to be affected both functionally and pathologically by AD [7][8][9]27], overexpression of ZnT3 and a resulting zinc distribution may play a role in the formation of senile plaques in the cerebellum.…”

“…Significant changes in biological functions associated with the cerebellum are often observed in advanced stages of AD [7][8][9]. Several studies have demonstrated a reduced nucleolar volume [10] and regression of dendritic trees of Purkinje cells [11], increased microglia [12], and the presence of Aβ deposits [13][14][15] in the AD cerebellum.…”

An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan

“…The histopathological hallmark is the formation of α-synuclein-positive and Gallyas-positive argyrophilic glial cytoplasmic inclusions 2 9 10 11 12. The inclusions may be also stained with ubiquitin,9 as found in this case.…”

“…In support of the central mechanism, a histochemical study has confirmed severe loss of putative chemosensitive neurons, accumulation of α-synuclein immunoreactive glial inclusions as well as marked fibre gliosis in the medulla in cases of MSA 10 11 12. Additionally, given that autonomic failure is a prominent feature of MSA, a pathological involvement of autonomic neurons would contribute to respiratory arrest in MSA 3 4.…”

“…However, the immunoreactivity was preserved for α-synuclein and ubiquitin, consistent with MSA. Aggregation of α-synuclein underlies α-synucleinopathies including MSA, Parkinson disease, dementia with Lewy bodies (LBs), diffuse LB disease and the LB variant of Alzheimer disease 9 10 11 12 13…”

Elevation of Zinc Transporter ZnT3 Protein in the Cerebellar Cortex of the AβPP/PS1 Transgenic Mouse

“…We also found that both ZnT3 immunofluorescence and AMG zinc are present in the amyloid plaques of the cerebellar cortex in AβPP/PS1 transgenic mice. Since the cerebellum is a brain region that is known to be affected both functionally and pathologically by AD [7][8][9]27], overexpression of ZnT3 and a resulting zinc distribution may play a role in the formation of senile plaques in the cerebellum.…”

“…Significant changes in biological functions associated with the cerebellum are often observed in advanced stages of AD [7][8][9]. Several studies have demonstrated a reduced nucleolar volume [10] and regression of dendritic trees of Purkinje cells [11], increased microglia [12], and the presence of Aβ deposits [13][14][15] in the AD cerebellum.…”