Non-coeliac sprue possibly related to methotrexate in a rheumatoid arthritis patient.

The citrulline generation test: proposal for a new enterocyte function test

“…One female participant in the HS group was excluded from further analysis for using methotrexate for quiescent rheumatoid arthritis. As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT 14, 15 . Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

“…As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT. 14,15 Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

The citrulline generation test: proposal for a new enterocyte function test

“…One female participant in the HS group was excluded from further analysis for using methotrexate for quiescent rheumatoid arthritis. As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT 14, 15 . Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

“…As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT. 14,15 Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

Sprue-like disease possibly related to a single dose of methotrexate

“…Three cases of non-coeliac sprue secondary to the use of methotrexate at low doses have been reported in the literature [1][2][3], either after relatively prolonged use (ten months) or after a single injection. A duodenal biopsy performed early or during treatment with methotrexate revealed villous atrophy.…”

Clinical-Pathological Conference Series from the Medical University of Graz

“…Diarrhea is indeed a common drug-associated adverse event, and the underlying mechanisms are often unclear [ 18 ]. Diarrhea due to drug-induced enteropathy has been reported for medications such as mycophenolate mofetil [ 19 , 20 ], methotrexate [ 21 , 22 ], azathioprine [ 23 ] and most recently olmesartan. Among the medications taken by our patient, only one, olmesartan, is associated with villous atrophy resulting in sprue-like enteropathy.…”

The citrulline generation test: proposal for a new enterocyte function test

“…One female participant in the HS group was excluded from further analysis for using methotrexate for quiescent rheumatoid arthritis. As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT 14, 15 . Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

“…As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT. 14,15 Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

Sprue-like disease possibly related to a single dose of methotrexate

“…Three cases of non-coeliac sprue secondary to the use of methotrexate at low doses have been reported in the literature [1][2][3], either after relatively prolonged use (ten months) or after a single injection. A duodenal biopsy performed early or during treatment with methotrexate revealed villous atrophy.…”

Clinical-Pathological Conference Series from the Medical University of Graz

“…Diarrhea is indeed a common drug-associated adverse event, and the underlying mechanisms are often unclear [ 18 ]. Diarrhea due to drug-induced enteropathy has been reported for medications such as mycophenolate mofetil [ 19 , 20 ], methotrexate [ 21 , 22 ], azathioprine [ 23 ] and most recently olmesartan. Among the medications taken by our patient, only one, olmesartan, is associated with villous atrophy resulting in sprue-like enteropathy.…”

The citrulline generation test: proposal for a new enterocyte function test

“…One female participant in the HS group was excluded from further analysis for using methotrexate for quiescent rheumatoid arthritis. As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT 14, 15 . Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

“…As this drug has been reported to cause malabsorption and histological changes in enterocytes, we were reluctant to include her data considering the aim to provide reference values for the CGT. 14,15 Baseline characteristics of the remaining 19 HS are shown in Table 2.…”

Sprue-like disease possibly related to a single dose of methotrexate

“…Three cases of non-coeliac sprue secondary to the use of methotrexate at low doses have been reported in the literature [1][2][3], either after relatively prolonged use (ten months) or after a single injection. A duodenal biopsy performed early or during treatment with methotrexate revealed villous atrophy.…”

Clinical-Pathological Conference Series from the Medical University of Graz

“…Diarrhea is indeed a common drug-associated adverse event, and the underlying mechanisms are often unclear [ 18 ]. Diarrhea due to drug-induced enteropathy has been reported for medications such as mycophenolate mofetil [ 19 , 20 ], methotrexate [ 21 , 22 ], azathioprine [ 23 ] and most recently olmesartan. Among the medications taken by our patient, only one, olmesartan, is associated with villous atrophy resulting in sprue-like enteropathy.…”