Non-cannabinoid constituents from a high potency Cannabis sativa variety

Abstract

Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and β-sitosteryl-3-O-β-D-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, α-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and β-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2–4 were inactive as analgesics.

Evaluating the Natural Fibre Reinforced Polymer Biocomposite for the Development of Novel Wound Dressing Materials

“…Recently, the total number of natural compounds identified in the plant fibre was greater than 500 28 . Radwan et al 29 stated that the complex macrocomposition of plant fibre with these natural compounds have the potential to exhibit antibacterial activity.…”

Minor oxygenated cannabinoids from high potency Cannabis sativa L.

“…Modification of the structures are limited to changes in the side-chain and the terpenoid portion of the molecule (ElSohly and Slade, 2005). The total number of natural cannabinoids identified in C. sativa L. was 66 in 1995, 70 in 2005 and 105 in 2014 (Ahmed et al, 2008a,b; Appendino et al, 2008; Radwan et al, 2008a,b, 2009; ElSohly and Slade, 2005; ElSohly and Gul, 2014; Ross and ElSohly, 1995). …”

“…In efforts to study the chemistry of high potency cannabis, a variety of new constituents were isolated (Radwan et al, 2008a,b, 2009; Ahmed et al, 2008a,b). Herein reported are the isolation and structure elucidation of nine new oxygenated cannabinoids ( 1 – 9 ) namely, 9α-hydroxyhexahydrocannabinol ( 1 ), 7-oxo-9α-hydroxy-hexahydrocannabinol ( 2 ), 10α-hydroxyhexa-hydrocannabinol ( 3 ), 10a R -hydroxyhexa-hydrocannabinol ( 4 ), Δ 9 -THC aldehyde A ( 5 ), 8-oxo-Δ 9 -THC ( 6 ), 10aR-hydroxy-10-oxo-Δ 8 -THC ( 7 ), 9α-hydroxy-10-oxo-Δ 6a,10a -THC ( 8 ), and 1′ S -hydroxycannabinol ( 9 ) along with other previously identified constituents.…”

Isolation of a New Flavonone Glycoside from Eria marginata

“…and 4-methoxy-9,10-dihydrophenanthrene-1,2,7-triol (6), 13 a phenanthrene, nudol (7), 11 two bibenzyls, 3,4'-dihydroxy-5-methoxy bibenzyl (8) 14 and batatasin III (9), 15 a oleanane triterpenod, β-amyrin (10), 16 two sterols, β-sitosterol (11) and β-sitosteryl-3-O-β-D-glucopyranoside-2'-O-palmitate (12), 17 vanillin (13) 18 and mannitol (14) 19 were determined by comparison of the obtained spectroscopic data with those reported in the literature. Compounds 2, 3, 6, 8, 9, 10, and 12-14 were isolated from the Eria genus for the first time and the others were originally obtained from E. marginata.…”