Nomograms based on preoperative multiparametric magnetic resonance imaging for prediction of molecular subgrouping in medulloblastoma: results from a radiogenomics study of 111 patients

Dasgupta, Archya; Gupta, Tejpal; Pungavkar, Sona; Shirsat, Neelam; Epari, Sridhar; Chinnaswamy, Girish; Mahajan, Abhishek; Janu, Amit; Moiyadi, Aliasgar; Kannan, Sadhana; Krishnatry, Rahul; Sastri, Goda Jayant; Jalali, Rakesh

doi:10.1093/neuonc/noy093

Cited by 55 publications

(91 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their cohort of adult WNT-pathway medulloblastoma, Zhao et al [28] found significant contrast enhancement in all 17 patients, which was either heterogeneous (82%) or solid (18%). In their cohort of 17 patients with WNT-pathway medulloblastoma, Dasgupta et al [31] reported intense contrast enhancement in all patients; 53% showed homogeneous enhancement, while the enhancement pattern was inhomogeneous in the remaining 47% of patients.…”

Section: Contrast-enhancement Patternmentioning

confidence: 97%

“…In the last decade or so, several investigators from across the world have tried to correlate semantic imaging features with molecular subgrouping in medulloblastoma. All such studies [21][22][23][24][25][26][27][28][29][30][31] reporting on the imaging genomics of medulloblastoma are briefly summarized in Table 1. While it is quite clear that no single imaging feature is pathognomonic of any particular subgroup, certain imaging characteristics are much more prevalent in one subgroup compared to others and may even be highly specific for an individual molecular subgroup.…”

Section: Specific Imaging Features In Medulloblastoma Subgroupsmentioning

confidence: 99%

“…[31] , WNT-MB was asoociated with smaller tumor size, homogeneous contrast uptake, and intratumoral hemorrhage SHH-MB was more likely to have lateralised and superior location, away from brainstem and presence of peri-tumoral edema Group 3 tumors were in midline location, with "fluffy" enhancement and higher incidence of metatstatic diasease Group 4 tumors were in midline and inferior in location with dilatation of superior recess of IVth ventricle; showed minimal or "patchy" contrast enhancement the CPA in 20% of patients. A study involving 17 patients with WNT-pathway medulloblastoma, Dasgupta and colleagues [31] reported the epicentre to be in the midline in the horizontal axis in 77% of patients; the remaining 23% showed extension along the cerebellar peduncle towards the foramen of Luschka and/or CPA. They also reported central (71%) or inferior (23%) location of these tumors on the vertical axis in the vast majority, with only 6% of patients having a rostral location.…”

Section: Conventional Mri Features and Diffusion Imagingmentioning

confidence: 99%

“…In the series by Dasgupta et al [31] , hemorrhage was identified on imaging in 18% patients with WNTsubgroup medulloblastoma (n = 17) compared to < 10% for other subgroups, necessitating the routine use of susceptibility-weighted or gradient-echo imaging for reliable identification.…”

Section: Intra-tumoral Hemorrhagementioning

confidence: 99%

“…The authors also reported the absence of hydrocephalus, macrometastasis, and hemorrhage as having very high specificity and positive predictive value for WNT-subgroup medulloblastoma. Dasgupta et al [31] reported the longest tumor dimension to be < 4 cm in > 35% of WNT-subgroup tumors compared to > 4 cm in > 80% of patients of other subgroups. The presence of cyst or cavity (71%) and perilesional edema (53%) can also be encountered frequently in adult WNT-subgroup medulloblastoma [28] .…”

Section: Other Imaging Featuresmentioning

confidence: 99%

See 4 more Smart Citations

Radiogenomics of medulloblastoma: imaging surrogates of molecular biology

Dasgupta¹,

Gupta²

2018

JTGG

Self Cite

View full text Add to dashboard Cite

Medulloblastoma is a heterogeneous disease comprising four molecular subgroups-wingless (WNT), sonic hedge hog (SHH), group 3, and group 4, with distinct developmental origins, unique transcriptional profiles, diverse phenotypes, and varying clinical outcomes. Magnetic resonance imaging (MRI) is the preferred first-line imaging modality in the diagnosis and staging of suspected brain tumors including medulloblastoma. It is being increasingly recognized that imaging features reflect underlying disease biology that can serve as independent predictive and prognostic biomarkers. Radiogenomics is an emerging field of research that aims to define relationships between non-invasive imaging features (radio-phenotypes) and genomic data/molecular markers (molecular phenotypes). Recent studies have reported encouraging data regarding imaging genomics of medulloblastoma with certain MRI features correlating with specific molecular subgroups. These include lateralized cerebellar location for SHH-subgroup; cerebellopontine angle location for WNT-subgroup; and inferior location with dilation of superior recess of the IVth ventricle for group 4 tumors. Minimal enhancement of primary tumor and ependymal metastases (infundibular/suprasellar) with mismatching pattern is a specific feature of group 4 medulloblastoma. A 5-metabolite signature profile on magnetic resonance spectroscopy reliably differentiates SHH-subgroup from non-WNT/non-SHH medulloblastoma. SHH-specific binary nomogram (location on horizontal and vertical axis, relationship with dorsal brainstem, pattern of contrast-enhancement, and peri-tumoral edema as discriminating imaging features) is associated with excellent predictive accuracy, followed by group 4-specific nomogram, with suboptimal accuracy of WNT and group 3-specific nomograms. The advent of deep machine-learning techniques and convoluted artificial neural networks should provide unique opportunities to further improve the accuracy of such radiogenomic correlation and prediction.

show abstract

Section: Contrast-enhancement Patternmentioning

confidence: 97%

Section: Specific Imaging Features In Medulloblastoma Subgroupsmentioning

confidence: 99%

Section: Conventional Mri Features and Diffusion Imagingmentioning

confidence: 99%

Section: Intra-tumoral Hemorrhagementioning

confidence: 99%

Section: Other Imaging Featuresmentioning

confidence: 99%

See 3 more Smart Citations

Radiogenomics of medulloblastoma: imaging surrogates of molecular biology

Dasgupta¹,

Gupta²

2018

JTGG

Self Cite

View full text Add to dashboard Cite

show abstract

MRI Radiomics Signature of Pediatric Medulloblastoma Improves Risk Stratification Beyond Clinical and Conventional MR Imaging Features

Zheng

Liu

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background: Prognostic evaluation is important for personalized treatment in children with medulloblastoma (MB). Limited data are available for risk stratification using a radiomics-based model. Purpose: To evaluate the incremental value of an MRI radiomics signature in stratifying the risk of pediatric MB in terms of overall survival (OS). Study type: Retrospective. Subjects: A total of 111 children (mean age 5.82 years) with pathologically confirmed MB divided into training and validation cohorts (77 and 34 children, respectively). Field Strength/Sequence: A 3 T, contrast-enhanced T1-weighted imaging with inversion recovery. Assessment: The study endpoint was OS defined as the time between the preoperative MRI study and death or last follow-up. The radiomics signature model and a clinical-MRI model were developed for personalized OS prediction. An integrative model, which combined the radiomics signature and clinical-MRI features, was also built using multivariable Cox regression model. The performance of the three models was evaluated with the C-index. The performance of integrative model was assessed by calibration curve and decision curve analysis (DCA). Statistical Tests: Independent T-test, Mann-Whitney U test, Fisher's exact tests or chi-square test, logistic regression analysis, Kaplan-Meier survival analysis, C-index, intraclass correlation coefficients (ICC). P < 0.05 was considered statistically significant. Results: The media OS was 2.83 years (3.87 AE 1.85 years). Two clinical and one conventional MR imaging features (remnant, adjuvant treatment, and peritumoral edema) were selected for clinical-MRI model building. The integrative model evaluated OS (C-index 0.823) better than either the radiomics signature (C-index 0.702) or the clinical-MRI model (C-index 0.771). And it also showed good performance in the validation cohort (C-indices: 0.786, 0.756, 0.721), which was validated by the good calibration (P > 0.05) and more benefit. Data Conclusions: This study demonstrated that the integrative model, which combined radiomics signature, clinical, and conventional MRI features, showed best performance in OS evaluation for children with MB. The radiomics signature may confer incremental value over clinical-MRI features. Evidence Level: 3. Technical Efficacy: Stage 2.

show abstract

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications

Dasgupta

Maitre

Pungavkar

et al. 2022

Methods in Molecular Biology

View full text Add to dashboard Cite

Nomograms based on preoperative multiparametric magnetic resonance imaging for prediction of molecular subgrouping in medulloblastoma: results from a radiogenomics study of 111 patients

Abstract: The predictive accuracy of MRI-based nomograms was excellent for SHH and encouraging for Group 4 medulloblastoma. Further work is needed for Group 3 and WNT-pathway medulloblastoma.

Cited by 55 publications

References 25 publications

Radiogenomics of medulloblastoma: imaging surrogates of molecular biology

Radiogenomics of medulloblastoma: imaging surrogates of molecular biology

MRI Radiomics Signature of Pediatric Medulloblastoma Improves Risk Stratification Beyond Clinical and Conventional MR Imaging Features

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications

Contact Info

Product

Resources

About