Nomenclature for factors of the HLA system, 2000

Marsh, Steven G.E.; Bodmer, Julia G.; Albert, E. D.; Bodmer, Walter F.; Bontrop, Ronald E.; Dupont, Bo; Erlich, Henry A.; Mach, Bernard; Mayr, Wolfgang R.; Parham, Peter; Petersdorf, Effie W.; Sasazuki, Takehiko; Schreuder, G. M. T.; Strominger, Jack L.; Svejgaard, A.; Terasaki, Paul I.

doi:10.1046/j.1365-2370.2001.00268.x

Cited by 106 publications

(125 citation statements)

References 101 publications

(21 reference statements)

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“…Analyses were carried out using an SPSS for windows statistical package. Alleles were assigned according to the nomenclature for factors of the HLA system (14). (Table 1).…”

Section: Introductionmentioning

confidence: 99%

HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma

Luongo¹,

Pirozzi²,

Caracò

et al. 2004

Tissue Antigens

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The current study focuses the analysis on the possible relationship between HLA allele frequency and clinical outcome of melanoma in a population of 382 Italian patients, as compared with 203 ethnically matched controls. In a 3-year follow-up study, results showed significant differences between groups of patients selected according to clinical stage, histology, and progression of the disease. A*01 seems to be correlated with a less aggressive variant of the disease, whereas DRB1*01-DQB1*0501 seems to be associated with metastatic progression of melanoma. Moreover, a negative association with B*13, B*44, as well as with DRB1*04-DQB1*0302 was found. A multivariate logistic regression model showed HLA-DRB1*04 to behave as an independent favorable prognostic marker of melanoma in our population (OR = 2.34, CI = 1.15-4.74).

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“…Analyses were carried out using an SPSS for windows statistical package. Alleles were assigned according to the nomenclature for factors of the HLA system (14). (Table 1).…”

Section: Introductionmentioning

confidence: 99%

HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma

Luongo¹,

Pirozzi²,

Caracò

et al. 2004

Tissue Antigens

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“…DRB1*1301 is a relevant risk factor peculiar of pediatric age. DRB1*0301 confirmed his role in children and, interestingly, among the adult patient population it is associated with a younger age [43,46,48]. The DR4 family of alleles seems not to be implicated in children, whereas in adults they have been accounted as a marker of a mild, late onset disease [45, 47, and 53].…”

Section: Aih Type 1 and Mhc Class II Moleculesmentioning

confidence: 96%

“…With the availability of high resolution, PCR-based, HLA typing methods, the molecular basis of this association became investigable [46]. The principal susceptibility alleles for AIH type 1 are DRB1*0301, DRB3*0101 and DRB1*0401 as a part of DR3 and DR4 linked alleles [47][48][49].…”

Section: Aih Type 1 and Mhc Class II Moleculesmentioning

confidence: 99%

Autoimmune Hepatitis: A Childhood Disease

Maggiore¹,

Sciveres²

2005

CPR

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Autoimmune hepatitis is a severe and unresolving inflammatory disease of the liver of unknown etiology carrying high morbidity and mortality. All ages and genders are concerned with a peak of incidence in girls in prepubertal age, even if the disease has been diagnosed as early as 6 months. Autoimmune hepatitis may be classified in two major subgroups on a presence of a specific set of autoantibodies: anti-smooth muscle mostly with anti-actin specificity and/or by antinuclear antibody in type 1 and anti-liver-kidney microsome and/or the anti-liver cytosol in type 2. The histological hallmark is "interface hepatitis", with a mononuclear cell infiltrate in the portal tracts, variable degrees of necrosis, and progressive fibrosis. The disease follows a chronic but fluctuating course usually progressing to cirrhosis and liver failure. The most frequent type onset is similar to that of an acute viral hepatitis with acute liver failure in some patients; about a third of patients have an insidious onset with progressive fatigue and jaundice while 10-15% are asymptomatic and are accidentally discovered by the finding of hepatomegaly and/or an increase of serum aminotransferase activity. Corticosteroids alone or in conjunction with azathioprine are the treatment of choice inducing remission in over 90% of patients. An alternative therapeutic strategy is cyclosporine. Withdrawal of immunosuppression is associated with high risk of relapse. Liver transplantation manages patients with decompensated liver disease unresponsive to "rescue" medical treatment.

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“…The name A* was officially assigned by the WHO Nomenclature Committee in February 2002. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report ( 1 ), names will be assigned to new sequences, as they are identified. Lists of such new names will be published in the following WHO nomenclature report.…”

mentioning

confidence: 99%

“…1 ), names will be assigned to new sequences, as they are identified. Lists of such new names will be published in the following WHO nomenclature report.…”

mentioning

confidence: 99%

Characterization of a new HLA‐A allele, A*0256, identified in a Caucasian individual

et al. 2002

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HLA-A typing by the PCR-SSP method in a male 21-year-old Caucasian individual revealed a very rare allele combination corresponding to a unique reaction pattern. Therefore, the result was examined using sequence-based typing. Sequencing of exons 2 and 3 of the HLA-A locus after allelic separation with specific primers revealed the sequence of a new allele, similar to A*0245. Sequencing of exons 1 and 4 resulted in no additional inconclusive positions. The sequence pattern of the new allele HLA-A*0256 might have been generated as a result of a double crossing over recombination of an A*0201 and either an A*03 or an A*11.

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Nomenclature for factors of the HLA system, 2000

Cited by 106 publications

References 101 publications

HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma

HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma

Autoimmune Hepatitis: A Childhood Disease

Characterization of a new HLA‐A allele, A*0256, identified in a Caucasian individual

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