Noise-induced hearing loss in zebrafish model: Characterization of tonotopy and sex-based differences

Han, Eun‐Jung; Lee, Dae Hyeok; Park, Saemi; Rah, Yoon Chan; Park, Hae-Chul; Choi, Jee Woong; Choi, June

doi:10.1016/j.heares.2022.108485

Cited by 12 publications

(9 citation statements)

References 63 publications

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“…Some previous studies have reported that noise exposure can increase the hearing threshold and cause the loss of hair cells in the cochlea (Shi et al, 2014;Wen et al, 2015;Zhang et al, 2017;Seist et al, 2021;Zheng et al, 2021;Han et al, 2022). Consistently, we also found that noise exposure can cause an increase of hearing threshold in mice.…”

Section: Noise Exposure Can Induce Hearing Loss and Down-regulate Ser...supporting

confidence: 91%

Resveratrol prevents hearing loss and a subregion specific- reduction of serotonin reuptake transporter induced by noise exposure in the central auditory system

Cheng

Shu²,

Zhang

et al. 2023

Front. Neurosci.

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Prolonged or excessive exposure to noise can lead to hearing loss, tinnitus and hypersensitivity to sound. The effects of noise exposure on main excitatory and inhibitory neurotransmitter systems in auditory pathway have been extensively investigated. However, little is known about aberrant changes in neuromodulator systems caused by noise exposure. In the current study, we exposed 2-month-old mice to a narrow band noise at 116 dB SPL for 6 h or sham exposure, assessed auditory brainstem responses as well as examined the expression of serotonin reuptake transporter (SERT) in the cochlear nucleus (CN), inferior colliculus (IC), and primary auditory cortex (Au1) using immunohistochemistry. We found that noise exposure resulted in a significant increase in hearing thresholds at 4, 8, 16, 24, and 32 kHz, as well as led to a significant reduction of SERT in dorsal cochlear nucleus (DCN), dorsal IC (ICd), external IC (ICe), and Au1 layers I-IV. This reduction of SERT in these subregions of central auditory system was partially recovered 15 or 30 days after noise exposure. Furthermore, we examined efficacy of resveratrol (RSV) on hearing loss and loss of SERT induced by noise exposure. The results demonstrated that RSV treatment significantly attenuated threshold shifts of auditory brainstem responses and loss of SERT in DCN, ICd, ICe, and Au1 layers I-IV. These findings show that noise exposure can cause hearing loss and subregion-specific loss of SERT in the central auditory system, and RSV treatment could attenuate noise exposure-induced hearing loss and loss of SERT in central auditory system.

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Section: Noise Exposure Can Induce Hearing Loss and Down-regulate Ser...supporting

confidence: 91%

Resveratrol prevents hearing loss and a subregion specific- reduction of serotonin reuptake transporter induced by noise exposure in the central auditory system

Cheng

Shu²,

Zhang

et al. 2023

Front. Neurosci.

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“…Given the similarities between goldfish and zebrafish otolith organs (Platt, 1993), an analogous organization is possible in zebrafish. Some studies have shown that noise overexposure of specific tones results in hair cell damage at defined regions of zebrafish saccule, consistent with tonotopic organization (Schuck and Smith, 2009;Breitzler et al, 2020;Han et al, 2022). Many fishes are also thought to use the lagena as part of their auditory system (Ladich and Schulz-Mirbach, 2016), although zebrafish lagenar hair cells do not begin to develop until 15 dpf, well after hearing onset (Bever and Fekete, 2002).…”

Section: Inner Ear Morphology In Zebrafishmentioning

confidence: 93%

Vestibular physiology and function in zebrafish

Baeza-Loya

Raible

2023

Front. Cell Dev. Biol.

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The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as peripheral vestibular organs, with the addition of the lagena and macula neglecta. The zebrafish inner ear can be easily studied due to its accessible location, the transparent tissue of larval fish, and the early development of vestibular behaviors. Thus, zebrafish are an excellent model for studying the development, physiology, and function of the vestibular system. Recent work has made great strides to elucidate vestibular neural circuitry in fish, tracing sensory transmission from receptors in the periphery to central computational circuits driving vestibular reflexes. Here we highlight recent work that illuminates the functional organization of vestibular sensory epithelia, innervating first-order afferent neurons, and second-order neuronal targets in the hindbrain. Using a combination of genetic, anatomical, electrophysiological, and optical techniques, these studies have probed the roles of vestibular sensory signals in fish gaze, postural, and swimming behaviors. We discuss remaining questions in vestibular development and organization that are tractable in the zebrafish model.

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“…The impact of noise exposure on the fish inner ear has been addressed in a few studies. Most researchers focused on the saccule, which is considered to play a major role in hearing in this taxon (see Ladich and Schulz-Mirbach, 2016;Schulz-Mirbach et al, 2019 for review), and reported evidence of a tonotopic organization of the saccular epithelia with the rostral region more sensitive to high-frequency noise and the caudal region affected by low frequencies (Breitzler et al, 2020;Enger, 1981;Han et al, 2022;Schuck and Smith, 2009;Smith et al, 2006;Smith et al, 2011).…”

Section: Noise-induced Hair Cell Lossmentioning

confidence: 99%

“…In our previous study, Breitzler et al (2020) exposed zebrafish to white noise at 150 dB re 1 μPa for 24 h and identified significant hair cell loss (up to 27%) mostly in the rostral region of the saccule. More recently, (Han et al, 2022) treated zebrafish with white noise generated by a woofer air speaker at 140 dB re 1 μPa for 6 h and reported up to 22% decrease in saccular hair cells also in the rostral region. Both studies found the highest auditory thresholds shifts at 1000 Hz (Han et al, 2022) and 1000-2000 Hz (Breitzler et al, 2020), and such high frequencies are typically detected in the rostral saccular region.…”

Section: Noise-induced Hair Cell Lossmentioning

confidence: 99%

“…More recently, (Han et al, 2022) treated zebrafish with white noise generated by a woofer air speaker at 140 dB re 1 μPa for 6 h and reported up to 22% decrease in saccular hair cells also in the rostral region. Both studies found the highest auditory thresholds shifts at 1000 Hz (Han et al, 2022) and 1000-2000 Hz (Breitzler et al, 2020), and such high frequencies are typically detected in the rostral saccular region.…”

Section: Noise-induced Hair Cell Lossmentioning

confidence: 99%

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Noise-induced damage in the zebrafish inner ear endorgans: evidence for higher acoustic sensitivity of saccular and lagenar hair cells

Lau

Vasconcelos

2023

Preprint

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The three otolithic endorgans of the inner ear are known to be involved in sound detection in different teleost fishes, yet their relative roles for auditory-vestibular functions within the same species remain unclear. In zebrafish (Danio rerio), saccule and utricle are thought to play key functions in encoding auditory and vestibular information, respectively, but the biological function of lagena is not clear. We hypothesized that the saccule is the main auditory endorgan and lagena might serve an auditory function given its connectivity to the saccule and dominant vestibular function of the utricle in this species. We investigated the acoustic sensitivity of the three otolithic endorgans in adult zebrafish by comparing the impact of acoustic trauma (continuous white noise at 168 dB for 24 h) on their sensory epithelia. Noise treatment caused hair cell loss in both saccule and lagena, but not in the utricle. This effect was identified immediately after acoustic treatment and did not increase 24h post trauma. Furthermore, hair cell loss was accompanied by a reduction in presynaptic activity measured based on Ribeye b expression but mainly in the saccule, supporting its main contribution for noise-induced hearing loss. Our findings support the hypothesis that the saccule plays a major role in hearing and that lagena is also acoustically affected but with less sensitivity most likely extending the species hearing dynamic range.

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Noise-induced hearing loss in zebrafish model: Characterization of tonotopy and sex-based differences

Cited by 12 publications

References 63 publications

Resveratrol prevents hearing loss and a subregion specific- reduction of serotonin reuptake transporter induced by noise exposure in the central auditory system

Resveratrol prevents hearing loss and a subregion specific- reduction of serotonin reuptake transporter induced by noise exposure in the central auditory system

Vestibular physiology and function in zebrafish

Noise-induced damage in the zebrafish inner ear endorgans: evidence for higher acoustic sensitivity of saccular and lagenar hair cells

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