Nodulocystic infantile acne occurring in a kindred of steatocystoma

Burket, J. M.

doi:10.1001/archderm.123.4.432

Cited by 14 publications

(17 citation statements)

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“…Of the case series, Hazen (Hazen et al 1983) reported onset of depression at 2 weeks in the six patients in their paper, while all three of the other case series reported onset at one month (Bruno et al 1984;Hull and Demkiw-Bartel 2000;Scheinman et al 1990). Other authors reported an onset of symptoms at two months after start of treatment (Bigby and Stern 1988;Burket and Storrs 1987;Hepburn 1990;Lindemayr 1986). Most of the other cases developed depression or committed suicide at some point during treatment (2-4 months after onset of treatment) although specific details are not always given (Barak et al 2005;Bravard et al 1993;Byrne and Hnatko 1995a;Cotterill and Cunliff 1997;Ng et al 2002;Scheinman et al 1990;Wysowski et al 2001b).…”

Section: Temporal Association Between Isotretinoin Treatment and Deprmentioning

confidence: 93%

“…One of the patients was rechallenged with isotretinoin and experienced a recurrence of symptoms 3 months after re-initiation of treatment. Several other authors have reported individual cases of abatement of symptoms of depression and/or suicidality after discontinuation of isotretinoin (Bigby and Stern 1988;Bravard et al 1993;Burket and Storrs 1987;Byrne and Hnatko 1995b;Duke and Guenther 1993;Ng et al 2002). For instance, Barak reported that 4/5 patients who developed psychosis after receiving isotretinoin had an improvement in symptoms with cessation of isotretinoin and treatment with antipsychotics (Barak et al 2005).…”

Section: Cases Of Challenge/dechallenge Related To Isotretinoin and Dmentioning

confidence: 99%

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The neurobiology of retinoic acid in affective disorders

Bremner

McCaffery

2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

144

154

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Current models of affective disorders implicate alterations in norepinephrine, serotonin, dopamine, and CRF/cortisol; however treatments targeted at these neurotransmitters or hormones have led to imperfect resolution of symptoms, suggesting that the neurobiology of affective disorders is incompletely understood. Until now retinoids have not been considered as possible contributors to affective disorders. Retinoids represent a family of compounds derived from Vitamin A that perform a large number of functions, many via the vitamin A product, retinoic acid. This signaling molecule binds to specific retinoic acid receptors in the brain which, like the glucocorticoid and thyroid hormone receptors, are part of the nuclear receptor superfamily and regulate gene transcription. Research in the field of retinoic acid in the CNS has focused on the developing brain, in part stimulated by the observation that isotretinoin (13-cis retinoic acid), an isomer of retinoic acid used in the treatment of acne, is highly teratogenic for the CNS. More recent work has suggested that retinoic acid may influence the adult brain; animal studies indicated that the administration of isotretinoin is associated with alterations in behavior as well as inhibition of neurogenesis in the hippocampus. Clinical evidence for an association between retinoids and depression includes case reports in the literature, studies of health care databases, and other sources. A preliminary PET study in human subjects showed that isotretinoin was associated with a decrease in orbitofrontal metabolism. Several studies have shown that the molecular components required for retinoic acid signaling are expressed in the adult brain ; the overlap of brain areas implicated in retinoic acid function and stress and depression suggest that retinoids could play a role in affective disorders. This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression.

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Section: Temporal Association Between Isotretinoin Treatment and Deprmentioning

confidence: 93%

Section: Cases Of Challenge/dechallenge Related To Isotretinoin and Dmentioning

confidence: 99%

The neurobiology of retinoic acid in affective disorders

Bremner

McCaffery

2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

144

154

View full text Add to dashboard Cite

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“…Furthermore, the physicians were asked to 150 encourage patients to participate in the study. This may have increased physician awareness of the study objectives, and thus it is possible that it had an impact on the implementation and compliance with the PPP.…”

Section: Isotretinoin Utilizationmentioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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“…In some types of acne, such as acne conglobata, hereditary factors are more apparent, and a correlation has been suggested between neonatal acne and familial hyperandrogenism [4]. Nodulocystic IA is often observed in relatives of patients with extensive steatocystoma, adolescent and postadolescent acne [31]. Fifty percent of postadolescent acne patients have at least one first-degree relative with the condition [32].…”

Section: Acne Geneticsmentioning

confidence: 99%

Acne in Infancy and Acne Genetics

2003

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Acne is a disease that can be seen in the first year of age, early childhood, prepubertal age and puberty. Neonatal acne is due mainly to considerable sebum excretion rate, and infantile acne because of high androgens of adrenal origin in girls and of adrenal and testes in boys. These pathogenic mechanisms are characteristic in these ages. Important factors like early onset of comedones and high serum levels of dehydroepiandrosterone sulfate are predictors of severe or long-standing acne in prepubertal age. Hereditary factors play an important role in acne. Neonatal, nodulocystic acne and conglobate acne has proven genetic influences. Postadolescent acne is related with a first-degree relative with the condition in 50% of the cases. Chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and MUC1 gene are involved in the pathogenesis of acne. Several other genes are being studied.

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Nodulocystic infantile acne occurring in a kindred of steatocystoma

Cited by 14 publications

References 0 publications

The neurobiology of retinoic acid in affective disorders

The neurobiology of retinoic acid in affective disorders

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Acne in Infancy and Acne Genetics

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