Nodular vasculitis associated with lung adenocarcinoma

Borges, Augusta; Brasileiro, Ana; Apetato, Margarida

doi:10.1590/abd1806-4841.20187741

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…Nodular vasculitis is a chronic relapsing lobular panniculitis with septal vasculitis. Its cause may be due to a hypersensitivity reaction to an antigenic stimulus [2]. Erythema induratum must be distinguished from erythema nodosum, nodular vasculitis, polyarteritis nodosa, tertiary syphilis, and other infectious and inflammatory panniculitides.…”

Section: Discussionmentioning

confidence: 99%

“…NV has been thought of as a delayed hypersensitivity response to an antigenic stimulus, originally associated with tuberculosis. However, some cases have been associated with both nontuberculous infections, such as hepatitis B virus, hepatitis C virus, HIV, and streptococci, and noninfectious conditions [2], such as autoimmune diseases [3] and inflammatory bowel disease [1]. Chronic exposure to cold and drugs [4] have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Nodular vasculitis or erythema induratum without cutaneous tuberculosis: An unusual presentation in an uncommon site

Mofarrah¹,

Jallab²,

Mofarrah³

et al. 2021

Our Dermatol Online

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Erythema induratum (EI) is a rare chronic disease, which occurs with cutaneous tuberculosis (TB). Nodular vasculitis, much rarer than erythema induratum, describes the same condition but without cutaneous TB, with lesions usually in the lower legs and rarely on the breasts. We report the case of a 46-year-old female with a history of crusted skin and necrotic lesions two years before, which, once self-limited, multiplied one month before and transferred to uncommon sites of the body, such as the breast. There was no evidence of other clinical presentations, and a chest X-ray gave no pathological findings. A biopsy was taken from the lesions, and the patient was diagnosed with erythema induratum without cutaneous tuberculosis, that is, nodular vasculitis. After treatment with calcineurin-inhibiting tacrolimus ointment, topical corticosteroids, and immunosuppressive oral azathioprine, the lesions improved.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nodular vasculitis or erythema induratum without cutaneous tuberculosis: An unusual presentation in an uncommon site

Mofarrah¹,

Jallab²,

Mofarrah³

et al. 2021

Our Dermatol Online

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“…A further category of non‐infectious cases of EI was introduced, termed NV, after other triggers were described 1,4 . Antigenic stimuli to EI/NV include colon and lung adenocarcinoma, 5 infections (chlamydia, nocardia, pseudomonas, fusarium, hepatitis B/C virus), autoimmune diseases (systemic lupus erythematosus and rheumatoid arthritis) and drugs (etanercept and propylthiouracil) 4 …”

Section: Main Textmentioning

confidence: 99%

Nodular vasculitis (erythema induratum) associated with systemic minocycline

Farrugia,

Cachia,

Betts

et al. 2023

Aust J Dermatology

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A 29‐year‐old Caucasian woman presented with a 3‐month history of bilateral lower limb swelling with painful erythematous nodules on shins without ulceration. She had been taking minocycline for acne vulgaris for 3 years. Biochemical investigations showed deranged liver function test with positive ANA and mixed antinuclear factor (ANF) pattern. A skin biopsy was in keeping with a diagnosis of nodular vasculitis. Her skin lesions and liver function test improved within 3 months of stopping the minocycline treatment. This case report raises the awareness that minocycline could be a potential cause of nodular vasculitis, patients on minocycline should be closely monitored and minocycline should ideally not be prescribed for more than 12 weeks, given the possible adverse effects.

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“…Some of the infectious causereported in previous studies for NV are Tuberculosis, Nocardia, Fusarium, Pseudomonas, Chlamydia, and hepatitis C virus (3)(4)(5). Some cases of NV have also been found associated with non-infectious conditions such as drugs (6,7), inflammatory bowel diseases (8), several autoimmune diseases (9), and rare malignant diseases (10,11). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are oral antidiabetic drugs that in-Nodular vasculitis (NV), first described by Montgomery in 1945 for erythema induratum-like lesions, is a rare form of panniculitis that is particularly localized on the calves.…”

Section: Introductionmentioning

confidence: 99%