Nodular Nonsuppurative Panniculitis

Genesis of fat emboli.

“…Acute pancreatic necrosis has been reported as a cause (Edmondson and Fields, 1942;Lynch, 1954), but a personal study of eight fatal cases failed to confirm this. In a fatal case of Weber-Christian disease the occurrence of fat embolism was attributed to the necrotizing 0 process in adipose tissue (Miller and Kritzler, 1943). A fatty liver may be regarded in the present context as a form of adipose tissue from 0000 00 which embolic fat might be liberated by trauma (Grondahl, 1911;Killian, 1931;Hallgren, Kerstell, Rudenstam, and Svanborg, 1966), by necrosis D (MacMahon and Weiss, 1929;Tonge, Hurley, and Ferguson, 1969), or even spontaneously and O | (Cammermeyer and Gjessing, 1951;Hartroft and Ridout, 1951;Kent, 1955;Lynch, Raphael, and Dixon, 1959).…”

Weber-Christian Disease with Visceral Involvement

“…Remissions can occur. Christian's original patient had a remission of three years' duration, and one patient was free of the disease 20 years after the initial diagnosis-see discussion at the end of the paper by Miller and Kritzler (1943). In the case of Tilden et al (1940), the patient died from miliary tuberculosis.…”

“…In the case of Tilden et al (1940), the patient died from miliary tuberculosis. Miller and Kritzler (1943) described the first necropsy to be made in the active stage of panniculitis, and their patient died of general debility with signs of liver insufficiency, and at necropsy acute focal necrosis of the liver and spleen with moderate fatty degeneration of the liver was found. Similarly, Bj0rnstad's (1951) patient died of cirrhosis and fatty degeneration of the liver, accompanied by macrocytic anaemia.…”

Sterile nodular panniculitis with lung and lymph node involvement in a Siberian tiger (<i>Panthera tigris altica</i>)

“…A few cases of organ or tissue involvement in nodular systemic panniculitis have been reported in humans, including the liver and spleen [ 11 , 14 ], heart [ 22 ], mesentery [ 13 ], bone marrow [ 3 ], and lung. With increased awareness of the disease, nodular panniculitis has since been diagnosed in other species, including horses [ 1 , 21 ], cats [ 2 , 4 , 16 , 23 ], and dogs [ 5 , 6 , 10 , 16 , 19 ], but visceral involvement of this disease has not been reported in any veterinary species to date.…”