Nocturnal and daytime panic attacks—comparison of sleep architecture, heart rate variability, and response to sodium lactate challenge

Sloan, Eileen P.; Natarajan, Madhu K.; Baker, Brian; Dorian, Paul; Mironov, Dmitry; Barr, Aiella; Newman, David; Shapiro, Colin M.

doi:10.1016/s0006-3223(98)00158-9

Cited by 55 publications

(38 citation statements)

References 19 publications

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“…Surveys document that insomnia is more frequent in patients with panic disorder than in control populations (15,16). Most (17)(18)(19)(20) but not all (21,22) of published studies of panic disorder that utilized objective methods of sleep recording (polysomnography) have found evidence of impaired sleep initiation and maintenance.…”

Section: Sleep In Panic Disordermentioning

confidence: 99%

“…This phenomenon adds to evidence from pharmacological challenge and treatment studies and twin and familial genetic data that endogenous neurobiological mechanisms can underlie anxiety. Specific mechanisms postulated to underlie sleep panic include increased sensitivity to increased carbon dioxide blood levels (29), irregular breathing during slow wave sleep (30), and rebound noradrenergic surges (17,18). A cognitive mechanism of sensitivity to and catastrophic interpretation of interoceptive stimuli has also been suggested to underlie sleep panic (25).…”

Section: Sleep Panic Attacksmentioning

confidence: 99%

“…Sodium lactate and pentagastrin challenges, which trigger panic attacks from wake states, have been demonstrated to also trigger panic attacks from sleep (31,32). Greater cardiac and respiratory responses to lactate infusion during sleep absent panic awakenings have also been noted (18,33). Findings that panicogenic triggers can elicit attacks from sleep states indicate that elevated basal arousal is not required for experimentally inducing panic.…”

Section: Sleep Panic Attacksmentioning

confidence: 99%

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Sleep and Anxiety Disorders

Mellman

2008

Sleep Medicine Clinics

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Section: Sleep In Panic Disordermentioning

confidence: 99%

Section: Sleep Panic Attacksmentioning

confidence: 99%

Section: Sleep Panic Attacksmentioning

confidence: 99%

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Sleep and Anxiety Disorders

Mellman

2008

Sleep Medicine Clinics

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“…Kalp hızı değişkenliğinin uykuda incelenmesi, uyanıklıktaki bozucu dış faktörlerin etkisinden uzak, tonik otonomik işlevin değerlendirilmesinde daha değerli sonuçlar alınmasını sağlayabilir. Ancak panik bozukluğu hastalarında sınırlı sayıdaki uykuda kalp hızı değişkenliği çalışmalarından tutarlı sonuçlar elde edilememiştir (17)(18)(19)(20). Bu nedenle bu çalışmada ilaç kullanmayan panik bozukluğu hastalarının polisomnografi çalışması ile kalp hızı değişkenliğinin zaman ve frekans-alanında analizi amaçlanmıştır.…”

Section: Introductionunclassified

Panik Bozukluğu Hastalarında Uykuda Kalp Hızı Değişkenliği

Yetkin¹,

Erdamar²,

Yokuşoğlu³

et al. 2014

jtsm

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Summary ÖzetIntroduction: Studies generally indicate that panic disorder patients have reduced heart rate variability (HRV), diminished vagal tone and relative sympathetic dominance. Despite a consistent profile of reduced HRV in PD patients during daytime assessments, sleep-based HRV studies have yielded inconsistent results. For this reason, we aimed to investigate cardiac autonomic function in PD patients using polysomnographic records. Materials and Methods: 15 non-medicated PD patients and 15 ageand sex-matched normal controls were studied on polysomnography on two consecutive nights. Data were extracted from the second night for analysis. Results: Patients showed poor sleep efficiency, increased the number of the awakenings, and longer sleep latency than controls. Comparison of time domain and frequency domain HRV parameters between PD patients and control subjects revealed that there were no statistically significant differences. Discussion: The results indicate that the sympathovagal balance might not be influenced in drug-free patients with panic disorder in the early stage of illness. (JTSM 2014;1:28-32)

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“…Patients with panic disorder and/or post-traumatic stress disorder (PTSD) have an altered HR variability during REM sleep, determined by frequency analysis of the time course changes in the electrocardiogram R-R interval (Mellman et al, 2004;Nishith et al, 2003;Sloan et al, 1999). Such patients show a higher sympathetic component in HR variability during this sleep period.…”

Section: Introductionmentioning

confidence: 99%

Arterial Pressure and Heart Rate Increase during REM Sleep in Adenosine A2A-Receptor Knockout Mice, but not in Wild-Type Mice

Sakata

Séi

Eguchi³

et al. 2005

Neuropsychopharmacol

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Rapid eye movement (REM)-sleep related changes in arterial pressure (AP) and heart rate (HR) were observed in homozygous and heterozygous adenosine A 2A receptor (A2AR) knockout (KO) mice, and the corresponding wild-type mice. During REM sleep, the mean AP (MAP) and HR were clearly increased in the homozygous A2AR KO mice, while, in the wild-type mice, they were decreased or maintained at the same level. Neither homozygous nor heterozygous A2AR KO mice showed significant difference in diurnal pattern and the hourly values of MAP and HR compared to the wild-type mice. From these findings, it is likely that the adenosine A2AR is involved in autonomic regulation during REM sleep.

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Nocturnal and daytime panic attacks—comparison of sleep architecture, heart rate variability, and response to sodium lactate challenge

Cited by 55 publications

References 19 publications

Sleep and Anxiety Disorders

Sleep and Anxiety Disorders

Panik Bozukluğu Hastalarında Uykuda Kalp Hızı Değişkenliği

Arterial Pressure and Heart Rate Increase during REM Sleep in Adenosine A2A-Receptor Knockout Mice, but not in Wild-Type Mice

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