Nocturia and associated morbidity in a Danish population of men and women aged 60–80 years

Abstract

OBJECTIVE To evaluate the association between nocturia and medical diseases, medication, urinary incontinence (UI), recurrent cystitis, smoking, alcohol, parity, hysterectomy, pelvic organ prolapse surgery, UI surgery, and prostate surgery. SUBJECTS AND METHODS The previously validated questionnaire the Nocturia, Nocturnal Enuresis and Sleep‐interruption Questionnaire was sent to 2000 women and 2000 men aged 60, 65, 70, 75, and 80 years. The population was selected at random from The Danish Civil Registration System. RESULTS Using multiple logistic regressions UI and age were significantly associated with nocturia irrespective of severity. Nocturia of ≥1 voids was significantly associated with body mass index (BMI), hypertension, and smoking; and nocturia of ≥2 voids with gender, BMI, diabetes and recurrent cystitis, as well as between nocturia of ≥3 voids and gender, lung disease, diabetes, use of diuretics and recurrent cystitis. Summarising the associations in an ordinal regression analysis UI (odds ratio (OR) 2.17, 95% CI 1.76–2.68), recurrent cystitis (OR 1.97, 95% CI 1.30–2.97) and diabetes (OR 1.89, 95% CI 1.32–1.65) had the strongest associations with nocturia. CONCLUSIONS Our results show that various disorders are associated with nocturia. However, the associations are strongly dependent on the severity of the nocturia.

Prevalence and risk factors for nocturia in middle-aged and elderly people from public health centers in Taiwan

“…In addition, the lack of arginine vasopressin (AVP) secretion and renal AVP resistance induced by diabetes may play a crucial role (20,21). People with obesity (BMI of > 27 kg/m 2 ) had higher odds for suffering from nocturia, as compared to those without obesity, which was consistent with numerous epidemiological studies (5,7,8,15,17). The exact mechanism by which obesity causes nocturia is not known.…”

“…Some earlier epidemiologic studies reported signifi cant associations of heart disease with nocturia (7-9), while others did not (6,10,11,17). A recent study conducted by Chiu et al demonstrated that patients with chronic heart failure suffer from three or more episodes of nocturia as compared to the controls (26).…”

Obstructive sleep apnea syndrome should be considered as a cause of nocturia in younger patients without other voiding symptoms

“…This lack of recognition is likely affected by the fact that nocturia is a common symptom among people ≥50 years old and is associated with a variety of clinical syndromes and diagnoses, including hypertension, diabetes, obesity, benign prostatic hyperplasia, and coronary artery disease. 13,14 Oztura et al reported that nocturia episodes were significantly more frequent among patients with sleep-related breathing disorders. 20 Chen et al have also reported that nocturia is an independent predictor of severe obstructive sleep apnea in patients with ischemic stroke.…”

“…11,12 Nocturia is another multifactorial disorder that can be caused by hypertension, diabetes, heart failure, or sleeping disorders. 13,14 OSAS can be an underlying cause of nocturia, although it is infrequently recognized, even in the field of urology. However, waking to urinate is an easily noticed and quantitative variable.…”

Nocturia, Insomnia Symptoms and Mortality among Older Men: The Health, Aging and Body Composition Study

“…3 As previously suggested, 19 the cause of nocturia among older men is most probably multifactorial, and this could explain the previously reported associations between frequent nocturia episodes and higher disease burden. 20,21 Additionally, previous…”