Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Filtjens, Jessica; Roger, A.; Quatrini, Linda; Wieduwild, Élisabeth; Gouilly, Jordi; Hoeffel, Guillaume; Rossignol, Rafaëlle; Daher, Clara; Debroas, Guilhaume; Henri, Sandrine; Jones, Claerwen M.; Malissen, Bernard; Mackay, Laura K.; Moqrich, Aziz; Carbone, Federico; Ugolini, Sophie

doi:10.1038/s41467-021-22841-6

Cited by 35 publications

(19 citation statements)

References 52 publications

(88 reference statements)

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“…Likewise, nociceptive sensory neurons were found to control herpes virus (HSV-1) infection in mice. They reduced skin inflammation by decreasing inflammatory cytokine secretion, monocyte activation and neutrophil infiltration in response to cutaneous infection by HSV-1, and by promoting CD8 T cell priming by skin DCs ( 73 ). Skin lymph nodes are indeed innervated by various subsets of sensory neurons, predominantly peptidergic nociceptors, whose stimulation by TLR agonists triggers rapid transcriptional changes in endothelium, stromal cells, and ILCs ( 74 ).…”

Section: Crosstalk Between the Two Systems Of Relationmentioning

confidence: 99%

The immune system as a system of relations

Daëron

2022

Front. Immunol.

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Progress in neuroimmunology established that the nervous and the immune systems are two functionally related physiological systems. Unique sensory and immune receptors enable them to control interactions of the organism with the inner and the outer worlds. Both systems undergo an experience-driven selection process during their ontogeny. They share the same mediators/neurotransmitters and use synapses for intercellular communication. They keep a memory of previous experiences. Immune cells can affect nervous cells, nervous cells can affect immune cells, and they regulate each other. I however argue that the two systems differ by three major points: 1) Unlike the nervous system, the immune system has a loose anatomical structure, in which molecular and cellular events mostly occur at random; 2) The immune system can respond to molecules of the living world whereas the nervous system can respond to phenomena of the physical world; 3) Responses of the immune system act both on the organism and on the stimulus that triggered the response, whereas responses of the nervous system act on the organism only. The nervous and the immune systems therefore appear as two complementary systems of relations that closely work together, and whose reactivities are well-suited to deal with physical and biological stimuli, respectively. Its ability both to adapt the organism to the living world and to adapt the living world to the organism endows the immune system with powerful adaptive properties that enable the organism to live in peace with itself and with other living beings, whether pathogens or commensals.

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Section: Crosstalk Between the Two Systems Of Relationmentioning

confidence: 99%

The immune system as a system of relations

Daëron

2022

Front. Immunol.

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“…Nav1.8 is a sodium channel, mainly expressed in C-fibers of sensory neurons in the dorsal root ganglia. During HSV-1 infection, Nav1.8 + nociceptors inhibit skin neutrophil infiltration, limit tissue damage, control dendritic cells (DCs) responses to antigen presentation, and induce the initiation of CD8 + T cells ( Filtjens et al, 2021 ).…”

Section: Neuroimmune Crosstalk In Skin Lung and Intestinementioning

confidence: 99%

“…This pathway enhances the skin’s defense against C. Albicans ( Kashem et al, 2015b ) and leads to psoriatic dermatitis ( Riol-Blanco et al, 2014 ). During HSV-1 infection, Nav1.8 + nociceptors are activated to inhibit skin neutrophil infiltration, limit tissue damage, and control DC responses to affect antigen presentation and induce the initiation of CD8 + T cells ( Filtjens et al, 2021 ).…”

Section: Neuroimmune Crosstalk In Skin Lung and Intestinementioning

confidence: 99%

Neuroimmune Interaction: A Widespread Mutual Regulation and the Weapons for Barrier Organs

Zhu

Duan

Wang

et al. 2022

Front. Cell Dev. Biol.

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Since the embryo, the nervous system and immune system have been interacting to regulate each other’s development and working together to resist harmful stimuli. However, oversensitive neural response and uncontrolled immune attack are major causes of various diseases, especially in barrier organs, while neural-immune interaction makes it worse. As the first defense line, the barrier organs give a guarantee to maintain homeostasis in external environment. And the dense nerve innervation and abundant immune cell population in barrier organs facilitate the neuroimmune interaction, which is the physiological basis of multiple neuroimmune-related diseases. Neuroimmune-related diseases often have complex mechanisms and require a combination of drugs, posing challenges in finding etiology and treatment. Therefore, it is of great significance to illustrate the specific mechanism and exact way of neuro-immune interaction. In this review, we first described the mutual regulation of the two principal systems and then focused on neuro-immune interaction in the barrier organs, including intestinal tract, lungs and skin, to clarify the mechanisms and provide ideas for clinical etiology exploration and treatment.

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“…Patients with AD can have a Th2‐induced decreased production of antimicrobial peptide (AMP), leading to an increased risk for colonization with Staphylococcus aureus or other pathogens 49 . During cutaneous herpes simplex virus 1 infections, nociceptive sensory neurons reduce neutrophil skin infiltration, promoting the induction of an antiviral CD8 T‐cell response 52 …”

Section: The Role Of T Cells In Inflammatory Skin Diseases Including ...mentioning

confidence: 99%

T‐cell subsets in the skin and their role in inflammatory skin disorders

Krohn

Aerts

Breckpot

et al. 2021

Allergy

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The human skin is a multifunctional organ that is essential for systemic homeostasis. Epidermal barrier formation provides a first line of defense against exogenous threats, including microbial and physical agents and regulates the water loss. Additionally, it actively contributes to immune responses as a sentinel organ via the release of cytokines and chemokines that alarm immune cells in case of skin damage or infection. Epidermal keratinocytes are known to produce thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 in response to environmental signals, which activates innate lymphoid cells (ILCs), T lymphocytes (T cells), mast cells (MCs), and eosinophils. This review focuses on the various cutaneous T-cell subsets and their role in inflammatory skin disorders, and skin tumors. T-cell subsets orchestrate disease pathophysiology by the production of particular cytokines, which in turn affects interactions with other immune cells, such as B cells, eosinophils, neutrophils, and MCs.Therefore, these adaptive immune responses play a central role in the many inflammatory skin diseases, but also in infections and skin cancer. Additionally, currently available T-cell targeted therapies and future directions will be addressed.

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Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Cited by 35 publications

References 52 publications

The immune system as a system of relations

The immune system as a system of relations

Neuroimmune Interaction: A Widespread Mutual Regulation and the Weapons for Barrier Organs

T‐cell subsets in the skin and their role in inflammatory skin disorders

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