Nociception, Pain, Negative Moods, and Behavior Selection

Baliki, Marwan N.; Apkarian, A. Vania

doi:10.1016/j.neuron.2015.06.005

Cited by 542 publications

(584 citation statements)

References 181 publications

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“…1), including areas that are associated with coding information about noxious stimuli and reactions to noxious stimuli, the modulation of such information, the production of affective interpretations, attentional and emotional responses, and decisionmaking 19,27,[32][33][34] . These brain areas include somatosensory, insular, cingulate and prefrontal cortices, and subcortical areas, including the amygdala, hippo campus, hypothalamus, ventral striatum, thalamus, periaqueductal grey, rostroventral medulla, numerous other brainstem areas and the cerebellum 19,27,31,32,[35][36][37] .…”

Section: Imaging Of Painmentioning

confidence: 99%

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

et al. 2017

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624 | OCTOBER 2017 | VOLUME 13 www.nature.com/nrneurol CONSENSUS STATEMENT © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d . NeuroethicsA field that studies the implications of neuroscience for human self-understanding, ethics, and policy. Arterial spin labellingAn MRI-based brain imaging technique that detects cerebral blood flow based on magnetic tagging of blood.Nevertheless, diverse groups -including patients, researchers, clinicians, pharmaceutical and medical device companies, insurers and the legal communityseek methods for evaluating chronic pain besides selfreporting. Patients seek objective testing to demonstrate the reality of an invisible condition that is sometimes subject to doubt, researchers seek brain imaging markers that provide scientific, diagnostic and prognostic information that cannot be provided by patient self-reporting, and legal representatives and officials seek techniques to supplement self-reporting and objectively support or challenge claims related to chronic pain. Brain imaging technologies, including functional MRI (fMRI), PET, EEG and magnetoencephalography (MEG), have the potential to provide objective measurements of patterns of brain activity that underlie perceptual experiences (BOX 1). Consequently, some people are looking to brain imaging to provide a window into the experience of chronic pain, particularly because testimony based on fMRI was deemed to be admissible as evidence of pain in a 2015 state trial court in the USA 10,11 . This case was highly publicized, although the judgement was not published so no legal precedent was set, and the grounds on which the fMRI evidence was admitted were criticized by established experts in brain imaging studies of pain 10,11 . In this context, the development of a brain imaging test for chronic pain [12][13][14] has real-world consequences, so appropriate criteria for the use of such a test must be defined. Importantly, the way in which brain imaging evidence might be implemented in legal cases strongly depends on laws that vary greatly between countries. Therefore, examination of the capability of so-called 'pain-o-meter' brain imaging tests is critical, as is consideration of the use of such technology in light of societal views, neuroethics and legal issues. Thus, the aims of this Consensus Statement are to recommend criteria for the evaluation of neuroimaging measures of chronic pain, and to discuss the technical, biological, neuroethical and legal challenges related to establishing brain-based tests for chronic pain. MethodsA presidential task force of the International Association for the Study of Pain (IASP) was established in 2015 to examine the feasibility of a brain-imaging-based diagnostic test for chronic pain. The task force had three purposes: to consider the capacity of brain imaging (in particular fMRI), on the basis of its technical and physiological constraints, to detect whether an individual has chronic pain; to place th...

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Section: Imaging Of Painmentioning

confidence: 99%

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

et al. 2017

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“…We recently proposed a 4-stage model for the transition from subacute to chronic pain (Baliki and Apkarian 2015). The model posits predisposing genetic and brain factors.…”

Section: Multiplicity Of Mechanisms Underlying the Brain Transitioninmentioning

confidence: 99%

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

et al. 2016

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Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain-that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models. We then review recent findings demonstrating the importance of the emotional brain (i.e., the corticolimbic system) in the modulation of acute pain and in the prediction and amplification of chronic pain, contrasting this evidence with recent findings regarding the role of central sensitization in pain chronification, especially for orofacial pain. We next elaborate on the corticolimbic circuitry and underlying mechanisms that determine the transition to chronic pain. Given this knowledge, we advance a new mechanistic definition of chronic pain and discuss the clinical implications of this new definition as well as novel therapeutic potentials suggested by these advances.

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“…Esto puede explicarse por la naturaleza nocioceptiva del dolor agudo (27), relacionado con las heridas agudas, ya que dentro del proceso de cicatrización ocurre una liberación intensa de sustancias algogénicas que activan los receptores cutáneos y los neurotransmisores, lo que lleva a que el niño manifieste cualidades sensoriales derivadas de la herida (27).…”

Section: Discussionunclassified

Instrumento tarjetas de cualidad del dolor: adaptación cultural y evidencias de validez en niños

Ramos¹,

Mariano-Rossato²,

Bueno³

et al. 2018

Aquichan

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Objetivo: evaluar la adaptación cultural y encontrar evidencias de validez del instrumento tarjetas de cualidad del dolor (ITCD). Materiales y método: estudio metodológico y de validación de pruebas, que para la adaptación y validación de contenido realizó la traducción, retrotraducción, panel de expertos, revisión por niños en edad escolar y prueba piloto del ITCD. Además, se evaluó la validez de criterio externo con 90 niños en edad escolar hospitalizados y con heridas. La investigación fue realizada entre enero y febrero del 2015. Resultados: el instrumento fue traducido y retrotraducido a español y a portugués, respectivamente. En la evaluación del panel de expertos fue establecido un índice de validez de contenido de 0,92. En la revisión realizada por los niños se efectuaron cambios a los descriptores de siete tarjetas según sus sugerencias. El estudio piloto, mostró que 17 tarjetas presentaron claridad semántica para más del 90% de los niños. En cuanto a las evidencias basadas en el criterio externo, las variables diagnóstico médico, tipo de herida, infección de la herida e intensidad del dolor mostraron resultados significativos (p<0,05). Conclusiones: el instrumento tarjetas de cualidad del dolor fue adaptado culturalmente y mostró evidencias de validez basadas en el contenido y en el criterio externo.

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Nociception, Pain, Negative Moods, and Behavior Selection

Cited by 542 publications

References 181 publications

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

Instrumento tarjetas de cualidad del dolor: adaptación cultural y evidencias de validez en niños

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