Nocardia cyriacigeorgica: pulmonary infection in a patient with Basedow–Graves disease and a short review of reported cases

Akçağlar, Sevim; Yılmaz, Emel; Heper, Yasemin; Alver, Oktay; Akalın, Halis; Ener, Beyza; Töre, Okan; Ersoy, Canan; İmamoğlu, Şazi

doi:10.1016/j.ijid.2007.06.014

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…The role of COPD in infection risk is not fully known [2]. We found seven patients with COPD who also suffered from an N. cyriacigeorgica pulmonary infection in the literature (table 1) [8][9][10][11].…”

Section: Pulmonary Nocardiosis In Immunocompetent Patients: Can Copd mentioning

confidence: 96%

Pulmonary nocardiosis in immunocompetent patients: can COPD be the only risk factor?

Rivière¹,

Billhot²,

Soler³

et al. 2011

Eur Respir Rev

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Section: Pulmonary Nocardiosis In Immunocompetent Patients: Can Copd mentioning

confidence: 96%

Pulmonary nocardiosis in immunocompetent patients: can COPD be the only risk factor?

Rivière¹,

Billhot²,

Soler³

et al. 2011

Eur Respir Rev

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“…This species has been rarely reported and overlooked in human infections so far, since molecular techniques for species identification have not been available [9]. Thus, the present isolate was initially identified only as Nocardia species by the API system.…”

Section: Discussionmentioning

confidence: 97%

Nocardia cyriacigeorgica bacteraemia presenting with cytomegalovirus disease and rapidly fatal pneumonia in a renal transplant patient: a case report

Namnyak

Uddin

Ahmod³

2011

J Med Case Reports

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IntroductionNocardia cyriacigeorgica bacteraemia has been described in the setting of profound immunodeficiency in only two previous case reports. In both instances, diagnosis was rapidly facilitated by 16S rRNA gene sequencing of blood culture isolates. To the best of our knowledge, we believe that our case is the first presentation of N. cyriacigeorgica bacteraemia associated with acute cytomegalovirus disease in a kidney transplant recipient, which was then followed by severe and fatal pneumonia only seven days later.Case presentationWe present the case of a 73-year-old Caucasian woman, a renal transplant recipient, with peripheral vascular disease, hypertension, osteoporosis and vascular dementia who was diagnosed with septicemia and pneumonia. In spite of appropriate anti-microbial therapy for nocardial sepsis, she developed severe pneumonia and acute renal failure.ConclusionThis case illustrates a potential for disseminated nocardial infection to produce clinical syndromes that may be indistinguishable from acute cytomegalovirus disease. An atypical presentation (pneumonia and renal failure) of a rare disease (nocardial septicemia) in the setting of renal transplantation is discussed. This case illustrates that the possibility of severe cytomegalovirus disease should be considered in renal transplanted patients diagnosed with nocardial septicemia who subsequently develop severe sepsis, pneumonia, and renal failure. Molecular diagnosis should readily be available to assist with the prompt diagnosis and treatment of these infections in renal transplant patients.

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“…In cases of N. veterana, Ansari et al reported that only one of nine cases developed disseminated nocardiosis, and the mortality rate was 11% (12). In N. cyriacigeorgica, Akcaglar et al reported that 14% of patients developed disseminated nocardiosis, and the mortality rate was 14% (13). Although the number of cases was limited and the disease severity depends on the immunity of the host, N. concava has the potential to cause severe infections in comparison with other Nocardia species.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Nocardiosis Caused by <i>Nocardia concava</i> with a Literature Review

et al. 2016

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A 68-year-old man was admitted to our hospital with anorexia and leg pain. He was diagnosed with ANCA-associated vasculitis through a renal biopsy. Immunosuppression with two courses of steroid pulse therapies and intravenous cyclophosphamide followed by oral prednisolone at 40 mg/day were administered. About one month after starting the immunosuppression therapy, he complained of hemosputum. Chest computed tomography showed a cavitary lesion in the lung. Cultures from his sputum showed Nocardia species, and we were able to identify the species as N. concava using a 16S rRNA gene sequence analysis. Only three detailed reports of N. concava infection have so far been published worldwide.

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Nocardia cyriacigeorgica: pulmonary infection in a patient with Basedow–Graves disease and a short review of reported cases

Cited by 12 publications

References 22 publications

Pulmonary nocardiosis in immunocompetent patients: can COPD be the only risk factor?

Pulmonary nocardiosis in immunocompetent patients: can COPD be the only risk factor?

Nocardia cyriacigeorgica bacteraemia presenting with cytomegalovirus disease and rapidly fatal pneumonia in a renal transplant patient: a case report

Pulmonary Nocardiosis Caused by <i>Nocardia concava</i> with a Literature Review

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