No lower bacterial adhesion for ceramics compared to other biomaterials: An in vitro analysis

Slullitel, Pablo; Buttaro, Martín; Greco, Graciela; Oñativia, José Ignacio; Sánchez, Marisa López; Loughlin, Santiago Mc; García-Ávila, C.; Zanotti, Gerardo; Piccaluga, Francisco

doi:10.1016/j.otsr.2018.03.003

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…It has been recently shown that bacterial adhesion is less important on porous alumina than on other materials such as titanium or stainless steel, 16,17 which is another asset in surgeries with risks of infection such as wide oncologic excision of the sternum.…”

Section: Discussionmentioning

confidence: 99%

Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

Mainard

Sharma

Fron

et al. 2022

European J Pediatr Surg Rep.

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Ewing's sarcoma is the second most frequent primary malignant bone tumor in adolescents and young adults. Locations on the thoracic wall represent up to 20% of primary and secondary locations. We present the case of a 13-year-old patient treated with the use of a radiolucency porous bioceramic prosthesis as a sternal replacement for a wide tumor resection in an oncologic context. Focal radiation therapy was not possible due to the high risk of severe myocardial injuries caused by the sternal location of the tumor. The sternum CERAMIL® (I.CERAM, Limoges, France), in porous alumina (Al2O3) has already been implanted into adults in sternal replacement during its invasion by a tumor or its infectious destruction. There were no complication concerning the surgery. The last follow-up at 2 years postoperatively reveals a satisfactory clinical situation with any functional thoracic complaint and nor any functional respiratory symptoms. The porous alumina sternal prosthesis offers a reliable alternative for sternal replacement indications for children in an oncologic context.

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Section: Discussionmentioning

confidence: 99%

Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

Mainard

Sharma

Fron

et al. 2022

European J Pediatr Surg Rep.

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“…The results can be compared to each other, since bacterial adhesion seems to be similar on different materials (i.e. cobalt-chrome, ceramics, titanium, polyethylene) 17 .…”

Section: Discussionmentioning

confidence: 99%

In vitro additive effects of dalbavancin and rifampicin against biofilm of Staphylococcus aureus

Jacob¹,

Makarewicz

Hartung

et al. 2021

Sci Rep

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Dalbavancin is a novel glycopeptide antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). It is characterized by a potent activity against numerous Gram-positive pathogens, a long elimination half-life and a favorable safety profile. Most recently, its application for the treatment of periprosthetic joint infections (PJIs) was introduced. The aim of this study was to proof our hypothesis, that dalbavancin shows superior efficacy against staphylococcal biofilms on polyethylene (PE) disk devices compared with vancomycin and additive behavior in combination with rifampicin. Staphylococcus aureus biofilms were formed on PE disk devices for 96 h and subsequently treated with dalbavancin, vancomycin, rifampicin and dalbavancin-rifampicin combination at different concentrations. Quantification of antibacterial activity was determined by counting colony forming units (CFU/ml) after sonification of the PE, serial dilution of the bacterial suspension and plating on agar-plates. Biofilms were additionally life/dead-stained and visualized using fluorescence microscopy. Dalbavancin presented superior anti-biofilm activity compared to vancomycin. Additive effects of the combination dalbavancin and rifampicin were registered. Dalbavancin combined with rifampicin presents promising anti-biofilm activity characteristics in vitro. Further in vivo studies are necessary to establish recommendations for the general use of dalbavancin in the treatment of PJIs.

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“…Recently, a new approach was suggested in which the implants are coated with a defensive antibacterial-coating hydrogel, which is supposed to reduce bacterial adhesion and biofilm formation [ 130 ]. Although the data on direct bacterial adhesion and biofilm formation on ceramic articulating surfaces in contrast to CoCr and Polyethylene remain controversial [ 137 , 138 ], the use of ceramic heads has been reported to be associated with a lower risk of revision for periprosthetic joint infection [ 139 ]. Hosman et al [ 140 ] suggested that wear debris from metal-on-metal bearing surfaces might accelerate the growth of bacteria.…”

Section: Current Trends and Future Perspectivesmentioning

confidence: 99%

Surgical Treatment of Bone Sarcoma

Bläsius

Delbrück

Hildebrand

et al. 2022

Cancers

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Bone sarcomas are rare primary malignant mesenchymal bone tumors. The three main entities are osteosarcoma, chondrosarcoma, and Ewing sarcoma. While prognosis has improved for affected patients over the past decades, bone sarcomas are still critical conditions that require an interdisciplinary diagnostic and therapeutic approach. While radiotherapy plays a role especially in Ewing sarcoma and chemotherapy in Ewing sarcoma and osteosarcoma, surgery remains the main pillar of treatment in all three entities. After complete tumor resection, the created bone defects need to be reconstructed. Possible strategies are implantation of allografts or autografts including vascularized bone grafts (e.g., of the fibula). Around the knee joint, rotationplasty can be performed or, as an alternative, the implantation of (expandable) megaprostheses can be performed. Challenges still associated with the implantation of foreign materials are aseptic loosening and infection. Future improvements may come with advances in 3D printing of individualized resection blades/implants, thus also securing safe tumor resection margins while at the same time shortening the required surgical time. Faster osseointegration and lower infection rates may possibly be achieved through more elaborate implant surface structures.

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No lower bacterial adhesion for ceramics compared to other biomaterials: An in vitro analysis

Abstract: IV, in vitro study.

Cited by 11 publications

References 25 publications

Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

In vitro additive effects of dalbavancin and rifampicin against biofilm of Staphylococcus aureus

Surgical Treatment of Bone Sarcoma

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