NO kidding: exhaled nitric oxide fraction in preschool children

Pijnenburg, Mariëlle; Merkus, Peter

doi:10.1183/09031936.00201814

Cited by 4 publications

(4 citation statements)

References 22 publications

(30 reference statements)

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“…1,2 FeNO is reproducible and easy to use in the clinic setting. [3][4][5] The FeNO measurement technique is often easier for younger children to master than spirometry 6 and much less invasive than sputum induction or bronchoscopy. 7,8 We assessed the ability of children 4 to 6 years of age to use a handheld, electrochemical, in vitro diagnostic device for measuring FeNO that operates using a 6-second exhalation mode or a 10-second exhalation mode (NIOX VERO, Circassia Pharmaceuticals Inc, Morrisville, North Carolina) and the degree of agreement between results obtained in each mode.…”

Section: Measurement Of Exhaled Nitric Oxide In Young Childrenmentioning

confidence: 99%

“…3 The forced oscillation technique (FOT) is a noninvasive method that is used to measure respiratory system resistance (Rrs) and reactance (Xrs) during tidal breathing. 4 The FOT is often used together with spirometry in airway reversibility tests. The greater changes in FOT parameters than those observed in spirometry suggest its usefulness in detecting airway reversibility and making a diagnosis of asthma.…”

Section: Acknowledgmentsmentioning

confidence: 99%

See 1 more Smart Citation

Measurement of exhaled nitric oxide in young children

Rickard¹,

MacDonald-Berko²,

Anolik

et al. 2019

Annals of Allergy, Asthma & Immunology

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Section: Measurement Of Exhaled Nitric Oxide In Young Childrenmentioning

confidence: 99%

Section: Acknowledgmentsmentioning

confidence: 99%

Measurement of exhaled nitric oxide in young children

Rickard¹,

MacDonald-Berko²,

Anolik

et al. 2019

Annals of Allergy, Asthma & Immunology

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show abstract

“…Obtaining reliable spirometry measurements can be difficult, and neither this nor other routinely available tests, such as the Childhood Asthma Control Test (C-ACT), provide information about airway inflammation [1]. In contrast, FeNO measurements are easy, quick to perform in the clinic, and reproducible [8][9][10]. In addition, FeNO testing uses a different respiratory maneuver to the other assessments, which does not involve a forced vital capacity maneuver.…”

Section: Introductionmentioning

confidence: 99%

“…When used to regularly monitor patients, FeNO has been shown to reduce exacerbations of both in adults [4,5] and in pediatric patients [6,7]. FeNO may also predict the development of persistent asthma, so methods to measure FeNO in younger patients is important [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Successful Fractional Exhaled Nitric Oxide Measurements with NIOX VERO using 6- and 10-s Exhalation Modes in Children with Asthma Aged 4–10 Years: A Randomized Study

Crater

Rickard

Jain³

2017

Pulm Ther

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NIOX VERO: Individualized Asthma Management in Clinical Practice

Carroll

2016

Pulm Ther

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As we move toward an era of precision medicine, novel biomarkers of disease will enable the identification and personalized treatment of new endotypes. In asthma, fractional exhaled nitric oxide (FeNO) serves as a surrogate marker of airway inflammation that often correlates with the presence of sputum eosinophils. The increase in FeNO is driven by an upregulation of inducible nitric oxide synthase (iNOS) by cytokines, which are released as a result of type-2 airway inflammation. Scientific evidence supports using FeNO in routine clinical practice. In steroid-naive patients and in patients with mild asthma, FeNO levels decrease within days after corticosteroid treatment in a dose-dependent fashion and increase after steroid withdrawal. In difficult asthma, FeNO testing correlates with anti-inflammatory therapy compliance. Assessing adherence by FeNO testing can remove the confrontational aspect of questioning a patient about compliance and change the conversation to one of goal setting and ways to improve disease management. However, the most important aspect of incorporating FeNO in asthma management is the reduction in the risk of exacerbations. In a recent primary care study, reduction of exacerbation rates and improved symptom control without increasing overall inhaled corticosteroid (ICS) use were demonstrated when a FeNO-guided anti-inflammatory treatment algorithm was assessed and compared to the standard care. A truly personalized asthma management approach-showing reduction of exacerbation rates, overall use of ICS and neonatal hospitalizations-was demonstrated when FeNO testing was applied as part of the treatment algorithm that managed asthma during pregnancy. The aim of this article is to describe how FeNO and the NIOX VERO Ò analyzer can help to optimize diagnosis and treatment choices and to aid in the monitoring and improvement of clinical asthma outcomes in children and adults.

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NO kidding: exhaled nitric oxide fraction in preschool children

Cited by 4 publications

References 22 publications

Measurement of exhaled nitric oxide in young children

Measurement of exhaled nitric oxide in young children

Successful Fractional Exhaled Nitric Oxide Measurements with NIOX VERO using 6- and 10-s Exhalation Modes in Children with Asthma Aged 4–10 Years: A Randomized Study

NIOX VERO: Individualized Asthma Management in Clinical Practice

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