No Association Between <i>Vitamin D Receptor</i> Polymorphisms and Coronary Artery Disease in a Chinese Population

Pan, Xue; Li, Dong-Ri; Yang, Lan; Wang, Enyin; Chen, Tian-Yi; Liu, Yaju; Liu, Min; Liao, Zihao

doi:10.1089/dna.2009.0908

Cited by 30 publications

(26 citation statements)

References 38 publications

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“…The present results were in agreement with that of Pan et al (2009) [43], in which no signi icant differences were observed in the genotype and allele frequencies of both BsmI and FokI polymorphisms between the two groups. Another study by Ortlepp et al (2003) [44], found that the VDR gene variant BsmI was not associated with prevalence and severity of coronary artery disease in a large-scale cohort phenotyped by angiography.…”

Section: Discussionsupporting

confidence: 92%

Profile of vitamin D receptor polymorphism Bsm I and FokI in end stage renal disease Egyptian patients on maintenance hemodialysis

Ha¹,

Mm²,

Ew³

2017

J Clini Nephrol

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Objective: In end stage renal disease, the synthesis of vitamin D is disturbed.Hyperparathyroidism is one of the key factors in the pathogenesis of many of the complications of dialysis mainly bone and cardiovascular complications.Aim:This study aimed at assessing vitamin D receptor gene polymorphisms BsmIand FokI in Egyptian patients with end stage renal disease on maintenance haemodialysis and the assosciation of these polymorphisms with cardiovascular complications and hyperparathyroidism among these patients. Methods:One hundred subjects, recruited from Medical Research Institute, from March to July 2014, divided into two main groups; the control group which included thirty apparently healthy subjects and the patients group which included seventy patients with end stage renal disease on maintenance haemodialysis with median 4 years. To all studied subjects, detailed history was taken, thorough physical examination, carotid intima media thickness, presence of plaques and ECG ischemic changes. Laboratory investigations included serum levels of: glucouse, urea, creatinine, uric acid, albumin, total cholesterol, low and high density lipoproteins, calcium, phosphorus, and CRP as well as plasma PTH level. For molecular studies, the detection of BsmI and FokI polymorphisms using polymerase chain reaction and restriction fragment length polymorphism (PCR / RFLP) technique.Results: 1.No statistically signifi cant difference could be detected in both BsmI and FokI gene polymorphisms between the hemodialysis patients and the controls, suggesting that the development of ESRD had no relation with either VDR BsmI or FokI gene polymorphisms.2.No statistically signifi cant difference were found in these polymorphisms between the hemodialysis patients with or without cardiovascular complications or between patients with PTH level less or more than 300 pg/ml. These results suggest that the development of cardiovascular complications and secondary hyperparathyroidism among Egyptian patients on maintenance haemodialysis cannot be attributed to these two gene polymorphisms. Conclusion:No association could be found between the variant alleles of BsmI and FokI gene polymorphisms and the development of ESRD, cardiovascular complications and secondary hyperparathyroidism among the studied samples of Egyptian patients on maintenance haemodialysis. Research

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Section: Discussionsupporting

confidence: 92%

Profile of vitamin D receptor polymorphism Bsm I and FokI in end stage renal disease Egyptian patients on maintenance hemodialysis

Ha¹,

Mm²,

Ew³

2017

J Clini Nephrol

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“…Ortlepp et al determined an association between the G/G genotype of VDR gene BsmI polymorphism and the risk of myocardial infarction in patients under the age of 65 [31]. The contradictory data were obtained by Shanker et al [32] and Pan et al [33] -they detected no association between polymorphic variants and haplotypes of the VDR gene and the development of coronary heart disease. Porojan et al examined the relation of VKORC1 allelic polymorphisms with atherosclerosis and calci- fi cation.…”

Section: Resultsmentioning

confidence: 99%

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

et al. 2015

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“…Of the 272 excluded studies, 44 were duplicate publications; 196 were not relevant to VDR gene polymorphisms and CAD risk; 12 were reviews, editorials, or comments; 4 were case reports; 5 were studies that reported on the association between other polymorphisms of the VDR gene and CAD risk; 4 were on patients with diabetes or kidney disorders; 2 were studies without any control group; and 8 were other irrelevant articles. A total of 8 relevant studies (cases, 5,259; controls, 1,981) were finally included based on the inclusion criteria for CAD susceptibility related to the Fok I, Bsm I, Taq I, and Apa I polymorphisms [24,25,26,27,28,29,30,31,32]. Of these, 7 studies were performed in Caucasians [24,25,26,27,29,30,32], and 2 studies [28,31] were performed in East-Asians.…”

Section: Resultsmentioning

confidence: 99%

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

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Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

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No Association Between Vitamin D Receptor Polymorphisms and Coronary Artery Disease in a Chinese Population

Cited by 30 publications

References 38 publications

Profile of vitamin D receptor polymorphism Bsm I and FokI in end stage renal disease Egyptian patients on maintenance hemodialysis

Profile of vitamin D receptor polymorphism Bsm I and FokI in end stage renal disease Egyptian patients on maintenance hemodialysis

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

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