No association between hair cortisol or cortisone and brain morphology in children

Chen, Ruoqing; Muetzel, Ryan L.; Marroun, Hanan El; Noppe, Gerard; Rossum, Elisabeth F.C. van; Jaddoe, Vincent W.V.; Verhulst, Frank C.; White, Tonya; Fang, Fang; Tiemeier, Henning

doi:10.1016/j.psyneuen.2016.08.023

Cited by 14 publications

(14 citation statements)

References 169 publications

(160 reference statements)

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“…Intra‐ and inter‐assay coefficients of variation for this assay are <10%. Hair cortisol values were log‐transformed to correct for skew, similar to previous methods (Chen et al., 2016). Additionally, parents currently using steroid medications were excluded from analysis ( n = 9).…”

Section: Methodsmentioning

confidence: 99%

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Infants of mothers with higher physiological stress show alterations in brain function

Troller‐Renfree

Brito

Desai

et al. 2020

Developmental Science

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Chronic environmental stress has deleterious effects on the developing child. While the type and degree of stress that children experience can vary widely, the downstream influence of varying stressors may impact child development similarly. Of particular interest is building an understanding of how chronic stress impacts brain functioning early in life, as both environmental stress and alterations in patterns of infant brain development have been related to a constellation of subsequent negative developmental outcomes. Among typically developing children, studies using electroencephalography (EEG) have shown that the relative contribution of low-frequency resting EEG power decreases with age, whereas the relative contribution of high-frequency resting EEG power increases with age (Marshall, Bar-Haim, & Fox, 2002). A variety of highly stressful environments have been linked to alterations

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Section: Methodsmentioning

confidence: 99%

“…Intra-and inter-assay coefficients of variation for this assay are <10%. Hair cortisol values were log-transformed to correct for skew, similar to previous methods (Chen et al, 2016).…”

Section: Hair Cortisol Collection and Analysismentioning

confidence: 99%

Infants of mothers with higher physiological stress show alterations in brain function

Troller‐Renfree

Brito

Desai

et al. 2020

Developmental Science

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show abstract

“…Chronically elevated cortisol levels have been linked to reduced hippocampal volumes in a variety of studies including different patient groups and healthy subjects of different sex and ages ( Travis et al, 2016 ; Babson et al, 2017 ; Wolf et al, 2002 ; Watanabe et al, 2017 ; Vachon-Presseau et al, 2013 ; Sudheimer et al, 2014 ; Starkman et al, 2003 ; Jin et al, 2016 ; Davis et al, 2017 ; Chen et al, 2016 ; Burkhardt et al, 2015 ; Brown et al, 2004 ) and have been linked to declarative memory deficits ( Coluccia et al, 2008 ; Starkman et al, 2003 ). Likewise, increased diurnal cortisol levels are related to reduced hippocampal activation ( Cunningham-Bussel et al, 2009 ).…”

Section: Neuroimaging Studies On the Effects Of Sex And Stress Hormonmentioning

confidence: 99%

Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus

Hillerer

Slattery

Pletzer

2019

Frontiers in Neuroendocrinology

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Men and women differ in their vulnerability to a variety of stress-related illnesses, but the underlying neurobiological mechanisms are not well understood. This is likely due to a comparative dearth of neurobiological studies that assess male and female rodents at the same time, while human neuroimaging studies often don’t model sex as a variable of interest. These sex differences are often attributed to the actions of sex hormones, i.e. estrogens, progestogens and androgens. In this review, we summarize the results on sex hormone actions in the hippocampus and seek to bridge the gap between animal models and findings in humans. However, while effects of sex hormones on the hippocampus are largely consistent in animals and humans, methodological differences challenge the comparability of animal and human studies on stress effects. We summarise our current understanding of the neurobiological mechanisms that underlie sex-related differences in behavior and discuss implications for stress-related illnesses.

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“…Hair cortisol concentrations (HCC) have been argued to reflect total free cortisol, and this is supported by a study that found associations between 30 days of multiple salivary collections and the most proximal 1 cm of hair growth (Short et al, ). Importantly, although one recent study found no relationship between brain morphology and HCC (Chen et al, ), another study reports that early‐life adversity moderates the relationship between left hippocampal volume and diurnal salivary cortisol levels, such that a relationship was only present in children with early‐life adversity (Dahmen et al, ). This suggests that early environment may be a key factor in explaining relationships with HPAA function; however, few studies have been conducted, to date, on HCC and early environments.…”

Section: Introductionmentioning

confidence: 99%

Correlates of hair cortisol concentrations in disadvantaged young children

et al. 2018

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Children from highly disadvantaged families tend to experience worse health, educational, and job outcomes than less disadvantaged peers. However, the mechanisms underlying these relationships remain to be explicated. In particular, few studies have investigated the relationships between the psychosocial influences that children are exposed to early in life and longer term cortisol output. This study aims to contribute to the literature by exploring how disadvantaged young children's experiences of family adversity, and parenting and family functioning, are related to their long‐term cortisol levels. A sample of 60 children (26 males, mean = 4.25 years, SD = 1.68) and their mothers (mean = 34.18 years, SD = 7.11) from a low‐income population took part in a single assessment. Mothers completed questionnaires on the family environment, parenting practices, and child behaviour. Children provided a hair sample for cortisol assay and anthropometric measures. A parsimonious multivariate regression model (including potential predictors identified by a selection algorithm) was used to investigate the correlates of hair cortisol concentration (HCC) in children. Higher levels of social exclusion, being male, and younger age were each associated with higher HCC. Maternal nurturing and emotion coaching were associated with lower HCC. Findings suggest that chronic stress may underlie relationships between adversity and its long‐term effects and that HCC offers a promising method for examining chronic stress in children and evaluating interventions by which it can be ameliorated.

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No association between hair cortisol or cortisone and brain morphology in children

Cited by 14 publications

References 169 publications

Infants of mothers with higher physiological stress show alterations in brain function

Infants of mothers with higher physiological stress show alterations in brain function

Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus

Correlates of hair cortisol concentrations in disadvantaged young children

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