NMR studies on penicillins: Hydrogen bonding, self-association and micellar solutions of cloxacillin Na-salt in D2O

Thermodynamics of Association of Structurally Related Amphiphilic Penicillins

“…Later studies reported the micellar properties of several synthetic penicillins (including cloxacillin) in water and in the presence of 0.15 M NaCl (4). The self-association of penicillins G and V was examined by gel filtration chromatography (5), and NMR techniques have been used in a study of penicillin G (6) and cloxacillin (7). We have recently reported the influence of electrolyte on the mode of association, micellar properties, and intermicellar interactions of cloxacillin, dicloxacillin, and flucoxacillin (8) and also analyzed the influence of the molecular structure on the ideality of mixing in micelles formed in binary mixtures of these amphiphiles (9).…”

Organometallic complexes with biological molecules. XVIII. Alkyltin(IV) cephalexinate complexes: synthesis, solid state and solution phase investigations

“…data problematic, has been reported therein. Additionally, the role of hydrogen bonding with solvent and weak intermolecular interactions between hydrophobic molecular fragments, both responsible for self-association and formation of micellar solutions of penicillins has been investigated by NMR [66].…”

Spectroscopic, thermal and X-ray powder diffraction patterns of Bi(V) complexes with [2S-[2𝛂, 5𝛂, 6𝛃(S*)]-6-[amino(4-hydroxyphenyl) acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0] hepatane-2-carboxylic acid and (6R)-6-(𝛂-phenyl-d-glycyamino) penicillinic acids

“…From the thermal decomposition several kinetics parameters such as activation energy (E*), enthalpy of activation (DH*), entropy of activation (DS*), free energy change (DG*) have been calculated by employing the Coats -Redfern relation (CR) [20] graphically.…”